Twenty-five elderly patients with untreated indolent non-Hodgkin lymphoma were treated with oral fludarabine 25 mg/m2/d (40 mg total dose) and cyclophosphamide 150 mg/m2/d, both for four consecutive days, repeated every 28 d for four cycles. In all, 21 (84%) patients were responsive: 10 patients achieved complete remission while partial response was obtained in 11. During an observation period of 37 months, there was an overall survival rate of 70% and a median event-free survival of 20 months. Haematological and extra-haematological toxicity were mild. This reduced-dose Flu-based oral regimen showed good efficacy and was simple to administer on an outpatient basis. © 2007 The Authors.

Fabbri, A., Lenoci, M., Gozzetti, A., Chitarrelli, I., Olcese, F., Raspadori, D., et al. (2007). Low-dose oral fludarabine plus cyclophosphamide as first-line treatment in elderly patients with indolent non-Hodgkin lymphoma. BRITISH JOURNAL OF HAEMATOLOGY, 139(1), 90-93 [10.1111/j.1365-2141.2007.06746.x].

Low-dose oral fludarabine plus cyclophosphamide as first-line treatment in elderly patients with indolent non-Hodgkin lymphoma

Gozzetti A.;Chitarrelli I.;Raspadori D.;Gobbi M.;
2007-01-01

Abstract

Twenty-five elderly patients with untreated indolent non-Hodgkin lymphoma were treated with oral fludarabine 25 mg/m2/d (40 mg total dose) and cyclophosphamide 150 mg/m2/d, both for four consecutive days, repeated every 28 d for four cycles. In all, 21 (84%) patients were responsive: 10 patients achieved complete remission while partial response was obtained in 11. During an observation period of 37 months, there was an overall survival rate of 70% and a median event-free survival of 20 months. Haematological and extra-haematological toxicity were mild. This reduced-dose Flu-based oral regimen showed good efficacy and was simple to administer on an outpatient basis. © 2007 The Authors.
Fabbri, A., Lenoci, M., Gozzetti, A., Chitarrelli, I., Olcese, F., Raspadori, D., et al. (2007). Low-dose oral fludarabine plus cyclophosphamide as first-line treatment in elderly patients with indolent non-Hodgkin lymphoma. BRITISH JOURNAL OF HAEMATOLOGY, 139(1), 90-93 [10.1111/j.1365-2141.2007.06746.x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1116175
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