In the annual evaluation of immunogenicity of influenza vaccines, HA antibody titer from patient sera is evaluated in order to assess whether a threshold level of immunity is obtained. So far, no other method has ever been used for this purpose. Here, we describe a method for the detection and titration of neuraminidase (NA) antibodies in immunized patients' sera. We believe this method might be helpful to better standardize influenza vaccines' immunological requirements prior to their commercialization.
Montomoli, E., Cavallaro, K., Alfonsi, V., Manini, I., Battisti, E., Provvedi, A., et al. (2004). A method for detection of neuraminidase antibody in serum. INTERNATIONAL CONGRESS SERIES, 1263(C), 524-527 [10.1016/j.ics.2004.02.067].
A method for detection of neuraminidase antibody in serum
MONTOMOLI, E.;ALFONSI, V.;MANINI, I.;BATTISTI, E.;
2004-01-01
Abstract
In the annual evaluation of immunogenicity of influenza vaccines, HA antibody titer from patient sera is evaluated in order to assess whether a threshold level of immunity is obtained. So far, no other method has ever been used for this purpose. Here, we describe a method for the detection and titration of neuraminidase (NA) antibodies in immunized patients' sera. We believe this method might be helpful to better standardize influenza vaccines' immunological requirements prior to their commercialization.
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https://hdl.handle.net/11365/11157
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