Fostemsavir is the prodrug of the HIV-1 attachment inhibitor temsavir and is currently under clinical assessment in heavily treatment-experienced patients with limited therapeutic options. We evaluated the genotypic and phenotypic susceptibility to temsavir in a panel of samples collected from patients harbouring MDR strains enrolled in the Italian PRESTIGIO Registry.
Saladini, F., Giannini, A., Giammarino, F., Maggiolo, F., Vichi, F., Corbelli, G.M., et al. (2020). In vitro susceptibility to fostemsavir is not affected by long-term exposure to antiviral therapy in MDR HIV-1-infected patients. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 75(9), 2547-2553 [10.1093/jac/dkaa178].
In vitro susceptibility to fostemsavir is not affected by long-term exposure to antiviral therapy in MDR HIV-1-infected patients
Saladini, Francesco
;Giannini, Alessia;Giammarino, Federica;Zazzi, Maurizio;
2020-01-01
Abstract
Fostemsavir is the prodrug of the HIV-1 attachment inhibitor temsavir and is currently under clinical assessment in heavily treatment-experienced patients with limited therapeutic options. We evaluated the genotypic and phenotypic susceptibility to temsavir in a panel of samples collected from patients harbouring MDR strains enrolled in the Italian PRESTIGIO Registry.
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https://hdl.handle.net/11365/1110652