Activin-A is a protein over-expressed and secreted by the brain after neuronal destruction. We evaluated whether serum activin-A increases in asphyxiated full-term newborns (AFTNs) at risk of hypoxic-ischemic-encephalopathy (HIE). 105 consecutive infants (35 affected by perinatal asphyxia due to acute fetal distress; 70 healthy gestational-age matched newborns) underwent cranial assessment and neurologic examination at 12, 24 and 72 hours after birth and, on discharge from the hospital and; activin-A and monitoring laboratory variables assessment at birth. According to the occurrence of HIE within 7-days after birth, AFTNs were subdivided in Group A (n= 20; no/mild HIE with good prognosis) and Group B (n= 15; moderate/severe HIE with a greater risk of neurological handicap). Activin-A was significantly (P less than 0.0001) higher in Groups A and B than controls and highest (P less than 0.001) in Group B. At 0.66 ng/L activin-A achieved a sensitivity of 93.33 per cent and a specificity of 96.63 per cent, respectively, as HIE diagnostic test. These findings show that activin A increased in AFTNs with HIE before the appearance of related signs

Florio, P., Frigiola, A., Battista, R., EL HADI ABDALLA, A., Gazzolo, D., Galleri, L., et al. (2010). Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. FRONTIERS IN BIOSCIENCE, 2(1), 36-42 [10.2741/e62].

Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy

FLORIO, P.;BATTISTA, R.;GALLERI, L.;PINZAUTI, S.;STRAMBI, M.
2010

Abstract

Activin-A is a protein over-expressed and secreted by the brain after neuronal destruction. We evaluated whether serum activin-A increases in asphyxiated full-term newborns (AFTNs) at risk of hypoxic-ischemic-encephalopathy (HIE). 105 consecutive infants (35 affected by perinatal asphyxia due to acute fetal distress; 70 healthy gestational-age matched newborns) underwent cranial assessment and neurologic examination at 12, 24 and 72 hours after birth and, on discharge from the hospital and; activin-A and monitoring laboratory variables assessment at birth. According to the occurrence of HIE within 7-days after birth, AFTNs were subdivided in Group A (n= 20; no/mild HIE with good prognosis) and Group B (n= 15; moderate/severe HIE with a greater risk of neurological handicap). Activin-A was significantly (P less than 0.0001) higher in Groups A and B than controls and highest (P less than 0.001) in Group B. At 0.66 ng/L activin-A achieved a sensitivity of 93.33 per cent and a specificity of 96.63 per cent, respectively, as HIE diagnostic test. These findings show that activin A increased in AFTNs with HIE before the appearance of related signs
Florio, P., Frigiola, A., Battista, R., EL HADI ABDALLA, A., Gazzolo, D., Galleri, L., et al. (2010). Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. FRONTIERS IN BIOSCIENCE, 2(1), 36-42 [10.2741/e62].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/11086
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