A method using planar chromatography (PC) was developed for determining lamotrigine (LTG; 3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) in human plasma and tablets. LTG was extracted with acetonitrile in the presence of sodium carbonate. 3,5-Diamino-6-(2-methoxyphenyl)-1,2,4-triazine was used as internal standard, The detection limit was 0.27 mu g/mL plasma and the recovery from human plasma fortified with various concentrations of LTG was 91.3 +/- 3.4%. Interference from other common antiepileptic agents was checked. Results obtained with the PC method were compared with those obtained by a method using liquid chromatography (LC) for analysis of plasma and with methods using LC and UV for assay of tablets.

Drenassi, E., Corbini, G., Corti, P., Ulivelli, M., Rocchi, R. (1996). Quantitative analysis of Lamotrigine in plasma and tablets by planar chromatography and comparison with liquid. JOURNAL OF AOAC INTERNATIONAL, 79(6), 1277-1280 [10.1093/jaoac/79.6.1277].

Quantitative analysis of Lamotrigine in plasma and tablets by planar chromatography and comparison with liquid

Corbini, Gianfranco;Ulivelli, Monica;Rocchi, Raffaele
1996-01-01

Abstract

A method using planar chromatography (PC) was developed for determining lamotrigine (LTG; 3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) in human plasma and tablets. LTG was extracted with acetonitrile in the presence of sodium carbonate. 3,5-Diamino-6-(2-methoxyphenyl)-1,2,4-triazine was used as internal standard, The detection limit was 0.27 mu g/mL plasma and the recovery from human plasma fortified with various concentrations of LTG was 91.3 +/- 3.4%. Interference from other common antiepileptic agents was checked. Results obtained with the PC method were compared with those obtained by a method using liquid chromatography (LC) for analysis of plasma and with methods using LC and UV for assay of tablets.
1996
Drenassi, E., Corbini, G., Corti, P., Ulivelli, M., Rocchi, R. (1996). Quantitative analysis of Lamotrigine in plasma and tablets by planar chromatography and comparison with liquid. JOURNAL OF AOAC INTERNATIONAL, 79(6), 1277-1280 [10.1093/jaoac/79.6.1277].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/11077
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