Phosphorus magnetic resonance spectroscopy (MRS) was used to study muscle phosphates metabolism in several brain disorders. Those with primary mitochondrial encephalomyopathies showed the typical pattern of impaired oxidative metabolism at rest and during recovery after exercise. In migraine, Parkinson's disease and alternating hemiplegia muscle MRS observations lend support to a possible mitochondrial dysfunction. Similar observations in multiple sclerosis are probably the result of secondary deconditioning. In post polio syndrome and in some of the hereditary ataxias, elevated intracellular inorganic phosphates may be the result of another, yet unknown, metabolic impairment. Thus, muscle phosphate metabolism may be altered in various central nervous system (CNS) disorders by different metabolic impairments. All these possibilities should be taken into account when evaluating MRS results in brain diseases.

Argov, Z., DE STEFANO, N., & Arnold, D.l. (1997). Muscle high-energy phosphates in central nervous system disorders. The phosphorus MRS experience. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 18(6), 353-357 [10.1007/BF02048238].

Muscle high-energy phosphates in central nervous system disorders. The phosphorus MRS experience.

DE STEFANO, NICOLA;
1997

Abstract

Phosphorus magnetic resonance spectroscopy (MRS) was used to study muscle phosphates metabolism in several brain disorders. Those with primary mitochondrial encephalomyopathies showed the typical pattern of impaired oxidative metabolism at rest and during recovery after exercise. In migraine, Parkinson's disease and alternating hemiplegia muscle MRS observations lend support to a possible mitochondrial dysfunction. Similar observations in multiple sclerosis are probably the result of secondary deconditioning. In post polio syndrome and in some of the hereditary ataxias, elevated intracellular inorganic phosphates may be the result of another, yet unknown, metabolic impairment. Thus, muscle phosphate metabolism may be altered in various central nervous system (CNS) disorders by different metabolic impairments. All these possibilities should be taken into account when evaluating MRS results in brain diseases.
Argov, Z., DE STEFANO, N., & Arnold, D.l. (1997). Muscle high-energy phosphates in central nervous system disorders. The phosphorus MRS experience. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 18(6), 353-357 [10.1007/BF02048238].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/11063
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