In patients with ALS, conventional MR imaging is frequently noninformative, and its use has been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive application of modern MR imaging-based techniques to the study of ALS has undoubtedly improved our understanding of disease pathophysiology and is likely to have a role in the identification of potential biomarkers of disease progression. This review summarizes how new MR imaging technology is changing dramatically our understanding of the factors associated with ALS evolution and highlights the reasons why it should be used more extensively in studies of disease progression, including clinical trials.

Agosta, F., Chiò, A., Cosottini, M., DE STEFANO, N., Falini, A., Mascalchi, M., et al. (2010). The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis. AJNR, AMERICAN JOURNAL OF NEURORADIOLOGY, 31(10), 1769-1777 [10.3174/ajnr.A2043].

The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis

DE STEFANO, NICOLA;
2010-01-01

Abstract

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive application of modern MR imaging-based techniques to the study of ALS has undoubtedly improved our understanding of disease pathophysiology and is likely to have a role in the identification of potential biomarkers of disease progression. This review summarizes how new MR imaging technology is changing dramatically our understanding of the factors associated with ALS evolution and highlights the reasons why it should be used more extensively in studies of disease progression, including clinical trials.
2010
Agosta, F., Chiò, A., Cosottini, M., DE STEFANO, N., Falini, A., Mascalchi, M., et al. (2010). The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis. AJNR, AMERICAN JOURNAL OF NEURORADIOLOGY, 31(10), 1769-1777 [10.3174/ajnr.A2043].
File in questo prodotto:
File Dimensione Formato  
168.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 2.81 MB
Formato Adobe PDF
2.81 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/11056
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo