Objective: The aim of the present study was to evaluate the changes in serum inhibin A, inhibin B and activin A levels in postmenopause. Methods: Specific assays for inhibin A, inhibin B and activin A were used and two groups of women were studied: 1) postmenopausal (n = 55) (aged 48-59 years), with a subgroup of 18 surgical menopause; 2) fertile healthy women (n = 50) (aged 19-35 years). The assays for inhibin A, inhibin B and activin A were two-site enzime immunoassay based on the use of plates coated with specific monoclonal antibodies; serum FSH, LH, 17β-estradiol levels were determined by radioimmunoassay. Results: Mean +/- SEM serum inhibin A and inhibin B levels in postmenopausal women were significantly lower than in fertile women (p < 0.01). The decreased levels of both inhibins were independent of the length or the type of menopause (natural or surgical). No significant difference of activin A levels was observed between postmenopausal and fertile women. Conclusion: The present study showed that both inhibin A and inhibin B levels decrease in postmenopausal women independently of age, length and form of menopause and they may represent a distinctive marker of ovarian failure. No changes of activin A levels has been observed after menopause suggesting that ovary is not the major source for circulating activin A.

Pezzani, I., Luisi, S., Santuz, M., Florio, P., Plaino, L., Fadalti, M., et al. (1998). Postmenopause is associated with a decrease in serum inhibin A and inhibin B levels but not in activin A. ITALIAN JOURNAL OF GYNAECOLOGY & OBSTETRICS, 10(3), 83-86.

Postmenopause is associated with a decrease in serum inhibin A and inhibin B levels but not in activin A

LUISI, S.;FLORIO, P.;
1998

Abstract

Objective: The aim of the present study was to evaluate the changes in serum inhibin A, inhibin B and activin A levels in postmenopause. Methods: Specific assays for inhibin A, inhibin B and activin A were used and two groups of women were studied: 1) postmenopausal (n = 55) (aged 48-59 years), with a subgroup of 18 surgical menopause; 2) fertile healthy women (n = 50) (aged 19-35 years). The assays for inhibin A, inhibin B and activin A were two-site enzime immunoassay based on the use of plates coated with specific monoclonal antibodies; serum FSH, LH, 17β-estradiol levels were determined by radioimmunoassay. Results: Mean +/- SEM serum inhibin A and inhibin B levels in postmenopausal women were significantly lower than in fertile women (p < 0.01). The decreased levels of both inhibins were independent of the length or the type of menopause (natural or surgical). No significant difference of activin A levels was observed between postmenopausal and fertile women. Conclusion: The present study showed that both inhibin A and inhibin B levels decrease in postmenopausal women independently of age, length and form of menopause and they may represent a distinctive marker of ovarian failure. No changes of activin A levels has been observed after menopause suggesting that ovary is not the major source for circulating activin A.
Pezzani, I., Luisi, S., Santuz, M., Florio, P., Plaino, L., Fadalti, M., et al. (1998). Postmenopause is associated with a decrease in serum inhibin A and inhibin B levels but not in activin A. ITALIAN JOURNAL OF GYNAECOLOGY & OBSTETRICS, 10(3), 83-86.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/10913
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