In this paper, we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter ε, representing the interface thickness between the tumorous and non-tumorous cells, tends to zero. More in particular, we analyze here a gradient-flow-type model arising from a modification of the recently introduced model for tumor growth dynamics in Hawkins-Daruud et al. (Int J Numer Math Biomed Eng 28:3–24, 2011) (cf. also Hilhorst et al. Math Models Methods Appl Sci 25:1011–1043, 2015). Exploiting the techniques related to both gradient flows and gamma convergence, we recover a condition on the interface Γ relating the chemical and double-well potentials, the mean curvature, and the normal velocity.
Rocca, E., Scala, R. (2017). A rigorous sharp interface limit for diffuse interface models related to tumor growth. JOURNAL OF NONLINEAR SCIENCE, 27(3), 847-872 [10.1007/s00332-016-9352-3].
A rigorous sharp interface limit for diffuse interface models related to tumor growth
SCALA R
2017-01-01
Abstract
In this paper, we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter ε, representing the interface thickness between the tumorous and non-tumorous cells, tends to zero. More in particular, we analyze here a gradient-flow-type model arising from a modification of the recently introduced model for tumor growth dynamics in Hawkins-Daruud et al. (Int J Numer Math Biomed Eng 28:3–24, 2011) (cf. also Hilhorst et al. Math Models Methods Appl Sci 25:1011–1043, 2015). Exploiting the techniques related to both gradient flows and gamma convergence, we recover a condition on the interface Γ relating the chemical and double-well potentials, the mean curvature, and the normal velocity.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1087422