The present study examined whether growth characteristics of diffusely growing non-Hodgkin's lymphomas (NHL) may differ as a function of stage. Among 105 NHL of various types and sub-types (REAL [Revised European-American Lymphoma] classification), localized (Ann Arbor pathologic stages I + II) lymphomas exhibited clearly higher indices for mitotic activity, apoptosis and cell turnover, as well as a significantly lower percentage of cells containing immunohistochemically detectable bcl-2 protein, than disseminated (stages III + IV) NHL. A similar pattern emerged when high-grade (Kiel classification) lymphomas only were evaluated. Low-grade NHL showed analogous, but less marked, stage-dependent characteristics, with the exception of median percentages of bcl-2(+) cells, which remained comparable in ail stages. Our findings are consistent with the notion that dissemination of diffusely growing NHL is usually associated with reduced cell turnover and, in high-grade lymphomas, with the generation of longer-lived cells. (C) 1996 Wiley-Liss, Inc.

Spina, D., Leoncini, L., Megha, T., Delvecchio, M.t., Minacci, C., Poggi, S., et al. (1996). Stage-related differences of mitotic and apoptotic indices, and bcl-2 protein expression in diffusely growing non-Hodgkin's lymphomas. INTERNATIONAL JOURNAL OF CANCER, 68(4), 436-440 [10.1002/(SICI)1097-0215(19961115)68:4<436::AID-IJC6>3.0.CO;2-1].

Stage-related differences of mitotic and apoptotic indices, and bcl-2 protein expression in diffusely growing non-Hodgkin's lymphomas

Spina, D;Leoncini, L;Megha, T;Minacci, C;Tosi, P;
1996-01-01

Abstract

The present study examined whether growth characteristics of diffusely growing non-Hodgkin's lymphomas (NHL) may differ as a function of stage. Among 105 NHL of various types and sub-types (REAL [Revised European-American Lymphoma] classification), localized (Ann Arbor pathologic stages I + II) lymphomas exhibited clearly higher indices for mitotic activity, apoptosis and cell turnover, as well as a significantly lower percentage of cells containing immunohistochemically detectable bcl-2 protein, than disseminated (stages III + IV) NHL. A similar pattern emerged when high-grade (Kiel classification) lymphomas only were evaluated. Low-grade NHL showed analogous, but less marked, stage-dependent characteristics, with the exception of median percentages of bcl-2(+) cells, which remained comparable in ail stages. Our findings are consistent with the notion that dissemination of diffusely growing NHL is usually associated with reduced cell turnover and, in high-grade lymphomas, with the generation of longer-lived cells. (C) 1996 Wiley-Liss, Inc.
Spina, D., Leoncini, L., Megha, T., Delvecchio, M.t., Minacci, C., Poggi, S., et al. (1996). Stage-related differences of mitotic and apoptotic indices, and bcl-2 protein expression in diffusely growing non-Hodgkin's lymphomas. INTERNATIONAL JOURNAL OF CANCER, 68(4), 436-440 [10.1002/(SICI)1097-0215(19961115)68:4<436::AID-IJC6>3.0.CO;2-1].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1076887