To better comprehend the relationships between cell birth and cell death in neoplastic disorders, the topography of these events needs to be considered. We applied a computerized nearest‐neighbor analysis to malignant, diffuse follicular‐center‐cell lymphomas in order to examine the spatial distribution of pyknotic (apoptotic) cells/bodies (A) and mitotic figures (M) in relation to capillaries (C) and venules (V). The results revealed a complex dispersion pattern, with significant aggregations of A and M, in addition to an even greater random distribution component. The greatest clustering displayed by A was around capillaries (A‐C, 42% reduction of object frequency between the first and second distance class), followed by A‐A (33%), A‐V (24%) and A‐M (12%). Additional values for mitotic figures were: M‐M (45%), M‐V (33%) and M‐C (22%). These findings may reflect the relative importance of inherent properties of the neoplastic and host factors, respectively, in the regulation of cell birth and cell death rates. © 1994 Wiley‐Liss, Inc. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company

Kraft, R., Barbini, P., Leoncini, L., Del Vecchio, M.T., Megha, T., Minacci, C., et al. (1994). Spatial distribution of mitosis, apoptosis and small blood vessels in malignant diffuse follicular‐center‐cell lymphomas: A nearest‐neighbor analysis. INTERNATIONAL JOURNAL OF CANCER, 59(3), 313-318 [10.1002/ijc.2910590304].

Spatial distribution of mitosis, apoptosis and small blood vessels in malignant diffuse follicular‐center‐cell lymphomas: A nearest‐neighbor analysis

Barbini P.;Leoncini L.;Del Vecchio M. T.;Megha T.;Minacci C.;Spina D.;Massai M. R.;Tosi P.;
1994-01-01

Abstract

To better comprehend the relationships between cell birth and cell death in neoplastic disorders, the topography of these events needs to be considered. We applied a computerized nearest‐neighbor analysis to malignant, diffuse follicular‐center‐cell lymphomas in order to examine the spatial distribution of pyknotic (apoptotic) cells/bodies (A) and mitotic figures (M) in relation to capillaries (C) and venules (V). The results revealed a complex dispersion pattern, with significant aggregations of A and M, in addition to an even greater random distribution component. The greatest clustering displayed by A was around capillaries (A‐C, 42% reduction of object frequency between the first and second distance class), followed by A‐A (33%), A‐V (24%) and A‐M (12%). Additional values for mitotic figures were: M‐M (45%), M‐V (33%) and M‐C (22%). These findings may reflect the relative importance of inherent properties of the neoplastic and host factors, respectively, in the regulation of cell birth and cell death rates. © 1994 Wiley‐Liss, Inc. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company
Kraft, R., Barbini, P., Leoncini, L., Del Vecchio, M.T., Megha, T., Minacci, C., et al. (1994). Spatial distribution of mitosis, apoptosis and small blood vessels in malignant diffuse follicular‐center‐cell lymphomas: A nearest‐neighbor analysis. INTERNATIONAL JOURNAL OF CANCER, 59(3), 313-318 [10.1002/ijc.2910590304].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1076885