Breast computed tomography (BCT) is an emerging application of X-ray tomography in radiological practice. A few clinical prototypes are under evaluation in hospitals and new systems are under development aiming at improving spatial and contrast resolution and reducing delivered dose. At the same time, synchrotron-radiation phase-contrast mammography has been demonstrated to offer substantial advantages when compared with conventional mammography. At Elettra, the Italian synchrotron radiation facility, a clinical program of phase-contrast BCT based on the free-space propagation approach is under development. In this paper, full-volume breast samples imaged with a beam energy of 32 keV delivering a mean glandular dose of 5 mGy are presented. The whole acquisition setup mimics a clinical study in order to evaluate its feasibility in terms of acquisition time and image quality. Acquisitions are performed using a high-resolution CdTe photon-counting detector and the projection data are processed via a phase-retrieval algorithm. Tomographic reconstructions are compared with conventional mammographic images acquired prior to surgery and with histologic examinations. Results indicate that BCT with monochromatic beam and free-space propagation phase- contrast imaging provide relevant three-dimensional insights of breast morphology at clinically acceptable doses and scan times.
|Titolo:||Advancements towards the implementation of clinical phase-contrast breast computed tomography at Elettra|
|Rivista:||JOURNAL OF SYNCHROTRON RADIATION|
|Citazione:||Longo, R., Arfelli, F., Bonazza, D., Bottigli, U., Brombal, L., Contillo, A., et al. (2019). Advancements towards the implementation of clinical phase-contrast breast computed tomography at Elettra. JOURNAL OF SYNCHROTRON RADIATION, 26(4), 1-11.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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