Although the route of sensitization to food allergens is still the subject of debate, it is generally accepted the gut immune system plays a pivotal role. However, hitherto the transport of allergens across the normal, pre-sensitized gut epithelium remained largely unknown. Our aim was to identify the route through which protein bodies and soluble proteins from digested peanuts penetrated the pre-sensitized gut epithelium in vivo and the specific cell types involved in the transport. Digestion of peanuts released a large number of protein bodies that are exclusively transported across the epithelium by specialized antigen-sampling M cells and delivered to the lymphoid tissue of Peyer’s patch. Intracellular transport of soluble protein also occurred almost exclusively via M cells and it was negligible across absorptive enterocytes. We hypothesize that these conditions which are known to favour strongly the induction of immune responses rather than oral tolerance may play a significant role in the genesis of allergic reactions.
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|Titolo:||Rapid in vivo transport of proteins from digested allergen across pre-sensitized gut|
|Citazione:||Chambers, S.j., Wickham, M., Regoli, M., Bertelli, E., Gunning, P.a., & Nicoletti, C. (2004). Rapid in vivo transport of proteins from digested allergen across pre-sensitized gut. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 325(4), 1258-1263.|
|Appare nelle tipologie:||1.1 Articolo in rivista|