Overexpression of P-glycoprotein (PGP), a multidrug-related (MDR) protein, is one of the most important factors responsible for reduced drug sensitivity in acute myeloid leukemia (AML). Recently, we demonstrated that the presence of CD56 antigen, an isoform of the neural adhesion molecule, in AML cells is a negative independent prognostic factor for the achievement of complete remission (CR) and correlates with shorter survival. Since in our previous report we observed a more frequent PGP expression in CD56+ patients, we hypothesized that the reduced response to chemotherapy in this group of patients was due to increased PGP-mediated drug efflux. To confirm this hypothesis in this study PGP and CD56 expression on AML cells was correlated with other clinical and biological features and treatment response.

Raspadori, D., Damiani, D., Michieli, M., Stocchi, R., Gentili, S., Gozzetti, A., et al. (2002). CD56 and PGP expression in acute myeloid leukemia: impact on clinical outcome. HAEMATOLOGICA, 87(11), 1135-40.

CD56 and PGP expression in acute myeloid leukemia: impact on clinical outcome

Raspadori, Donatella;Gozzetti, Alessandro;Lauria, Francesco
2002-01-01

Abstract

Overexpression of P-glycoprotein (PGP), a multidrug-related (MDR) protein, is one of the most important factors responsible for reduced drug sensitivity in acute myeloid leukemia (AML). Recently, we demonstrated that the presence of CD56 antigen, an isoform of the neural adhesion molecule, in AML cells is a negative independent prognostic factor for the achievement of complete remission (CR) and correlates with shorter survival. Since in our previous report we observed a more frequent PGP expression in CD56+ patients, we hypothesized that the reduced response to chemotherapy in this group of patients was due to increased PGP-mediated drug efflux. To confirm this hypothesis in this study PGP and CD56 expression on AML cells was correlated with other clinical and biological features and treatment response.
Raspadori, D., Damiani, D., Michieli, M., Stocchi, R., Gentili, S., Gozzetti, A., et al. (2002). CD56 and PGP expression in acute myeloid leukemia: impact on clinical outcome. HAEMATOLOGICA, 87(11), 1135-40.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1063423
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