Fine needle aspiration cytology (FNAC) represents the gold standard for determining the nature of thyroid nodules. It is a reliable method with good sensitivity and specificity. However, indeterminate lesions remain a diagnostic challenge and researchers have contributed molecular markers to search for in cytological material to refine FNAC diagnosis and avoid unnecessary surgeries. Nowadays, several “home-made” methods as well as commercial tests are available to investigate the molecular signature of an aspirate. Moreover, other markers (i.e., microRNA, and circulating tumor cells) have been proposed to discriminate benign from malignant thyroid lesions. Here, we review the literature and provide data from our laboratory on mutational analysis of FNAC material and circulating microRNA expression obtained in the last 6 years.

Cantara, S., Marzocchi, C., Pilli, T., Cardinale, S., Forleo, R., Castagna, M.g., et al. (2017). Molecular signature of indeterminate thyroid lesions: Current methods to improve fine needle aspiration cytology (FNAC) diagnosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(4), 775 [10.3390/ijms18040775].

Molecular signature of indeterminate thyroid lesions: Current methods to improve fine needle aspiration cytology (FNAC) diagnosis

Cantara S
;
Pilli T;Cardinale S;Forleo R;Castagna MG;Pacini F.
2017-01-01

Abstract

Fine needle aspiration cytology (FNAC) represents the gold standard for determining the nature of thyroid nodules. It is a reliable method with good sensitivity and specificity. However, indeterminate lesions remain a diagnostic challenge and researchers have contributed molecular markers to search for in cytological material to refine FNAC diagnosis and avoid unnecessary surgeries. Nowadays, several “home-made” methods as well as commercial tests are available to investigate the molecular signature of an aspirate. Moreover, other markers (i.e., microRNA, and circulating tumor cells) have been proposed to discriminate benign from malignant thyroid lesions. Here, we review the literature and provide data from our laboratory on mutational analysis of FNAC material and circulating microRNA expression obtained in the last 6 years.
2017
Cantara, S., Marzocchi, C., Pilli, T., Cardinale, S., Forleo, R., Castagna, M.g., et al. (2017). Molecular signature of indeterminate thyroid lesions: Current methods to improve fine needle aspiration cytology (FNAC) diagnosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(4), 775 [10.3390/ijms18040775].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1061401
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