The safety of vaccines is a critical factor in maintaining public trust in national vaccination programs. Vaccines are recommended for children, adults and elderly subjects and have to meet higher safety standards, since they are administered to healthy subjects, mainly healthy children. Although vaccines are strictly monitored before authorization, the possibility of adverse events and/or rare adverse events cannot be totally eliminated. Two main types of influenza vaccines are currently available: parenteral inactivated influenza vaccines and intranasal live attenuated vaccines. Both display a good safety profile in adults and children. However, they can cause adverse events and/or rare adverse events, some of which are more prevalent in children, while others with a higher prevalence in adults. The aim of this review is to provide an overview of influenza vaccine safety according to target groups, vaccine types and production methods.

Trombetta, C.M., Gianchecchi, E., Montomoli, E. (2018). Influenza vaccines: Evaluation of the safety profile. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 14(3), 657-670 [10.1080/21645515.2017.1423153].

Influenza vaccines: Evaluation of the safety profile

Trombetta, Claudia Maria;Montomoli, Emanuele
2018-01-01

Abstract

The safety of vaccines is a critical factor in maintaining public trust in national vaccination programs. Vaccines are recommended for children, adults and elderly subjects and have to meet higher safety standards, since they are administered to healthy subjects, mainly healthy children. Although vaccines are strictly monitored before authorization, the possibility of adverse events and/or rare adverse events cannot be totally eliminated. Two main types of influenza vaccines are currently available: parenteral inactivated influenza vaccines and intranasal live attenuated vaccines. Both display a good safety profile in adults and children. However, they can cause adverse events and/or rare adverse events, some of which are more prevalent in children, while others with a higher prevalence in adults. The aim of this review is to provide an overview of influenza vaccine safety according to target groups, vaccine types and production methods.
2018
Trombetta, C.M., Gianchecchi, E., Montomoli, E. (2018). Influenza vaccines: Evaluation of the safety profile. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 14(3), 657-670 [10.1080/21645515.2017.1423153].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1059310