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EnglishControversy still exists regarding the role of the TGF-β in neovascular age-related macular degeneration (nAMD), a major cause of severe visual loss in the elderly in developed countries. Here, we measured the concentrations of active TGF-β1, TGF-β2, and TGF-β3 by ELISA in the aqueous humor of 20 patients affected by nAMD, who received 3 consecutive monthly intravitreal injections of anti-VEGF-A antibody. Samples were collected at baseline (before the first injection), month 1 (before the second injection), and month 2 (before the third injection). The same samples were used in a luciferase-based reporter assay to test the TGF-β pathway activation. Active TGF-β1 concentrations in the aqueous humor were below the minimum detectable dose. Active TGF-β2 concentrations were significantly lower at baseline and at month 1, compared to controls. No significant differences in active TGF-β3 concentration were found among the sample groups. Moreover, TGF-β pathway activation was significantly lower at baseline compared to controls. Our data corroborate an anti-angiogenic role for TGF-β2 in nAMD. This should be considered from the perspective of a therapy using TGF-β inhibitors.
Tosi, G.M., Neri, G., Caldi, E., Fusco, F., Bacci, T., Tarantello, A., et al. (2018). TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration. SCIENTIFIC REPORTS, 8(1), 1-9.
| Titolo: | TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration |
| Autori: | GALVAGNI, FEDERICO (Corresponding) |
| Rivista: | |
| Citazione: | Tosi, G.M., Neri, G., Caldi, E., Fusco, F., Bacci, T., Tarantello, A., et al. (2018). TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration. SCIENTIFIC REPORTS, 8(1), 1-9. |
| Anno: | 2018 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| TGF-beta-concentration-2018-SciRep.pdf | PDF editoriale |  | Open Access Visualizza/Apri |
http://hdl.handle.net/11365/1058854
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