BACKGROUND: An engineered glove measuring finger motor performance previously showed ability to discriminate early-stage multiple sclerosis (MS) patients from healthy controls (HC). Radiologically isolated syndrome (RIS) classifies asymptomatic subjects with brain MRI abnormalities suggestive of multiple sclerosis. METHODS: We assessed 17 asymptomatic subjects with radiologically isolated syndrome (RIS) and 17 HC. They performed finger-to-thumb opposition sequences at their maximal velocity, metronome-paced bimanual movements and conventional and diffusion tensor MRI. RESULTS: Subjects with RIS showed lower (p=0.005) maximal velocity and higher (p=0.006) bimanual coordination impairment than HC. In RIS, bimanual coordination correlated with T2-lesion volume, fractional anisotropy and radial diffusivity in the white matter. CONCLUSIONS: These findings point out the relevance of fine hand measures as a robust marker of subclinical disability. This article is protected by copyright. All rights reserved.
|Titolo:||Subclinical motor impairment assessed with an engineered glove correlates with magnetic resonance imaging tissue damage in radiologically isolated syndrome|
DE STEFANO, NICOLA (Corresponding)
|Appare nelle tipologie:||1.1 Articolo in rivista|
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