BACKGROUND: An engineered glove measuring finger motor performance previously showed ability to discriminate early-stage multiple sclerosis (MS) patients from healthy controls (HC). Radiologically isolated syndrome (RIS) classifies asymptomatic subjects with brain MRI abnormalities suggestive of multiple sclerosis. METHODS: We assessed 17 asymptomatic subjects with radiologically isolated syndrome (RIS) and 17 HC. They performed finger-to-thumb opposition sequences at their maximal velocity, metronome-paced bimanual movements and conventional and diffusion tensor MRI. RESULTS: Subjects with RIS showed lower (p=0.005) maximal velocity and higher (p=0.006) bimanual coordination impairment than HC. In RIS, bimanual coordination correlated with T2-lesion volume, fractional anisotropy and radial diffusivity in the white matter. CONCLUSIONS: These findings point out the relevance of fine hand measures as a robust marker of subclinical disability. This article is protected by copyright. All rights reserved.
Bonzano, L., Bove, M., Sormani, M.P., Stromillo, M.L., Giorgio, A., Amato, M.P., et al. (2019). Subclinical motor impairment assessed with an engineered glove correlates with magnetic resonance imaging tissue damage in radiologically isolated syndrome. EUROPEAN JOURNAL OF NEUROLOGY, 26(1), 162-167 [10.1111/ene.13789].
Subclinical motor impairment assessed with an engineered glove correlates with magnetic resonance imaging tissue damage in radiologically isolated syndrome
Stromillo, Maria Laura;Giorgio, Antonio;De Stefano, Nicola
2019-01-01
Abstract
BACKGROUND: An engineered glove measuring finger motor performance previously showed ability to discriminate early-stage multiple sclerosis (MS) patients from healthy controls (HC). Radiologically isolated syndrome (RIS) classifies asymptomatic subjects with brain MRI abnormalities suggestive of multiple sclerosis. METHODS: We assessed 17 asymptomatic subjects with radiologically isolated syndrome (RIS) and 17 HC. They performed finger-to-thumb opposition sequences at their maximal velocity, metronome-paced bimanual movements and conventional and diffusion tensor MRI. RESULTS: Subjects with RIS showed lower (p=0.005) maximal velocity and higher (p=0.006) bimanual coordination impairment than HC. In RIS, bimanual coordination correlated with T2-lesion volume, fractional anisotropy and radial diffusivity in the white matter. CONCLUSIONS: These findings point out the relevance of fine hand measures as a robust marker of subclinical disability. This article is protected by copyright. All rights reserved.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1058121