Introduction: Lung cancer represents the leading cause of cancer mortality across the worlds. At present, less than 30% of the patients can undergo curative surgery, while the majority of them (65%) are diagnosed with metastatic disease and directed to systemic treatments. In this context there is a subset of patients (25%) with locally advanced stage disease whose outcome might be improved by using combined strategies of treatment including chemotherapy, radiotherapy and surgery. Areas covered: Here we reviewed possible combination strategies aimed to improve the outcome of lung cancer patients, focusing on the role of radiotherapy both in the adjuvant and oligo-metastatic setting and in synergy with immunotherapy, and finally, we afforded the new challenges concerning the advanced RT and precision oncology. We carried out a focused analysis concerning the key clinical management weaknesses as well as the potential that current research holds. Expert commentary: We believe that the most promising clinical trials in this specific patient subset will build their rationale on the results of well-designed translational models aimed to test the combination of cytotoxic drugs, radiobiology, and immune-pharmacology. In this context, remarkable investigational fields are focused on the attempt to combine radiotherapy with chemo-immunological strategies and precision medicine protocols.
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|Titolo:||The effects of radiotherapy on the survival of patients with unresectable non-small cell lung cancer|
|Citazione:||The effects of radiotherapy on the survival of patients with unresectable non-small cell lung cancer / Tini, Paolo; Nardone, Valerio; Pastina, Pierpaolo; Pirtoli, Luigi; Correale, Pierpaolo; Giordano, Antonio. - In: EXPERT REVIEW OF ANTICANCER THERAPY. - ISSN 1473-7140. - 18:6(2018), pp. 593-602.|
|Appare nelle tipologie:||1.1 Articolo in rivista|