G-protein coupled receptors (GPCRs) represent the largest receptor family in the genome and are of great interest for the design of novel drugs in a wide variety of diseases including neurologic disorders, obesity and Type 2 diabetes mellitus. The latter is a chronic disease characterized by insulin resistance and impaired insulin secretion, affecting >400 million patients worldwide. Here we provide an overview on: a) The molecular basis of GPCR signalling and of its involvement in the regulation of insulin secretion and of glucose homeostasis; b) the role of GPCRs in type 2 diabetes pathophysiology and as therapeutic targets of current and future glucose-lowering drugs.

Sebastiani, G., Ceccarelli, E., Castagna, M.g., Dotta, F. (2018). G-protein coupled receptors (GPCRs) in the treatment of diabetes: Current view and future perspectives. BAILLIERE'S BEST PRACTICE & RESEARCH. CLINICAL ENDOCRINOLOGY & METABOLISM, 32(2), 201-213 [10.1016/j.beem.2018.02.005].

G-protein coupled receptors (GPCRs) in the treatment of diabetes: Current view and future perspectives

Sebastiani G;Ceccarelli E;Castagna MG;Dotta F.
2018-01-01

Abstract

G-protein coupled receptors (GPCRs) represent the largest receptor family in the genome and are of great interest for the design of novel drugs in a wide variety of diseases including neurologic disorders, obesity and Type 2 diabetes mellitus. The latter is a chronic disease characterized by insulin resistance and impaired insulin secretion, affecting >400 million patients worldwide. Here we provide an overview on: a) The molecular basis of GPCR signalling and of its involvement in the regulation of insulin secretion and of glucose homeostasis; b) the role of GPCRs in type 2 diabetes pathophysiology and as therapeutic targets of current and future glucose-lowering drugs.
Sebastiani, G., Ceccarelli, E., Castagna, M.g., Dotta, F. (2018). G-protein coupled receptors (GPCRs) in the treatment of diabetes: Current view and future perspectives. BAILLIERE'S BEST PRACTICE & RESEARCH. CLINICAL ENDOCRINOLOGY & METABOLISM, 32(2), 201-213 [10.1016/j.beem.2018.02.005].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1036610