Herein we report a domino protocol able to reach regioselectively thiazolylidene systems by combining the reactive peculiarities of both β-amidothioamides (ATAs) and 1,2-diaza-1,3-dienes (DDs). Depending on the reaction conditions and/or the nature of the residue at C4 of the heterodiene system, ATAs can act as hetero-mononucleophiles or hetero-dinucleophiles in the diversified thiazolylidene ring assembly.

Santeusanio, S., Majer, R., Perrulli, F.R., De Crescentini, L., Favi, G., Giorgi, G., et al. (2017). Divergent approach to thiazolylidene derivatives: a perspective on the synthesis of a heterocyclic skeleton from β‑amidothioamides reactivity. JOURNAL OF ORGANIC CHEMISTRY, 82(18), 9773-9778 [10.1021/acs.joc.7b02135].

Divergent approach to thiazolylidene derivatives: a perspective on the synthesis of a heterocyclic skeleton from β‑amidothioamides reactivity

Giorgi, Gianluca;
2017

Abstract

Herein we report a domino protocol able to reach regioselectively thiazolylidene systems by combining the reactive peculiarities of both β-amidothioamides (ATAs) and 1,2-diaza-1,3-dienes (DDs). Depending on the reaction conditions and/or the nature of the residue at C4 of the heterodiene system, ATAs can act as hetero-mononucleophiles or hetero-dinucleophiles in the diversified thiazolylidene ring assembly.
File in questo prodotto:
File Dimensione Formato  
JOC_2017_santeusanio.pdf

non disponibili

Tipologia: PDF editoriale
Licenza: PUBBLICO - Pubblico con Copyright
Dimensione 685.5 kB
Formato Adobe PDF
685.5 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/1030441