Vaccination remains the principal way to control seasonal infections and is the most effective method of reducing influenza-associated morbidity and mortality. Since the 1940s, the main method of producing influenza vaccines has been an egg-based production process. However, in the event of a pandemic, this method has a significant limitation, as the time lag from strain isolation to final dose formulation and validation is six months. Indeed, production in eggs is a relatively slow process and production yields are both unpredictable and highly variable from strain to strain. In particular, if the next influenza pandemic were to arise from an avian influenza virus, and thus reduce the egg-laying hen population, there would be a shortage of embryonated eggs available for vaccine manufacturing. Although the production of egg-derived vaccines will continue, new technological developments have generated a cell-culture-based influenza vaccine and other more recent platforms, such as synthetic influenza vaccines.

Manini, I., Trombetta, C.M., Lazzeri, G., Pozzi, T., Rossi, S., Montomoli, E. (2017). Egg-Independent Influenza Vaccines and Vaccine Candidates. VACCINES, 5(3), 1-8 [10.3390/vaccines5030018].

Egg-Independent Influenza Vaccines and Vaccine Candidates

MANINI, ILARIA;TROMBETTA, CLAUDIA MARIA;LAZZERI, GIACOMO;POZZI, TERESA;ROSSI, STEFANIA;MONTOMOLI, EMANUELE
2017-01-01

Abstract

Vaccination remains the principal way to control seasonal infections and is the most effective method of reducing influenza-associated morbidity and mortality. Since the 1940s, the main method of producing influenza vaccines has been an egg-based production process. However, in the event of a pandemic, this method has a significant limitation, as the time lag from strain isolation to final dose formulation and validation is six months. Indeed, production in eggs is a relatively slow process and production yields are both unpredictable and highly variable from strain to strain. In particular, if the next influenza pandemic were to arise from an avian influenza virus, and thus reduce the egg-laying hen population, there would be a shortage of embryonated eggs available for vaccine manufacturing. Although the production of egg-derived vaccines will continue, new technological developments have generated a cell-culture-based influenza vaccine and other more recent platforms, such as synthetic influenza vaccines.
2017
Manini, I., Trombetta, C.M., Lazzeri, G., Pozzi, T., Rossi, S., Montomoli, E. (2017). Egg-Independent Influenza Vaccines and Vaccine Candidates. VACCINES, 5(3), 1-8 [10.3390/vaccines5030018].
File in questo prodotto:
File Dimensione Formato  
Egg-independent-influenza-Vaccines-2017.pdf

accesso aperto

Tipologia: PDF editoriale
Licenza: Creative commons
Dimensione 568.26 kB
Formato Adobe PDF
568.26 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1012441