Toscana virus (TOSV) is a phlebotomus-transmitted virus that belongs to the family Bunyaviridae and causes widespread infections in humans; about 30% of these cases result in aseptic meninigitis. In the present study, it was shown that TOSV is an inducer of beta interferon (IFN-β), although its non-structural protein (NSs) could inhibit the induction of IFN-β if expressed in a heterologous context. A recombinant Rift Valley fever virus expressing the TOSV NSs could suppress IFN-β expression in infected cells. Moreover, in cells expressing NSs protein from a cDNA plasmid, IFN-β transcripts were not inducible by poly(I : C). Unlike other members of the family Bunyaviridae, TOSV appears to express an NSs protein that is a weak antagonist of IFN induction. Characterization of the interaction of TOSV with the IFN system will help our understanding of virus-host cell interactions and may explain why the pathogenesis of this disease is mostly mild in humans.

GORI SAVELLINI, G., Weberb, F., Terrosi, C., Habjan, M., Martorelli, B., & Cusi, M.G. (2011). Toscana virus induces interferon although its NSs protein reveals antagonistic activity. JOURNAL OF GENERAL VIROLOGY, 92(1), 71-79 [10.1099/vir.0.025999-0].

Toscana virus induces interferon although its NSs protein reveals antagonistic activity.

GORI SAVELLINI, GIANNI;TERROSI, CHIARA;MARTORELLI, BARBARA;CUSI, MARIA GRAZIA
2011

Abstract

Toscana virus (TOSV) is a phlebotomus-transmitted virus that belongs to the family Bunyaviridae and causes widespread infections in humans; about 30% of these cases result in aseptic meninigitis. In the present study, it was shown that TOSV is an inducer of beta interferon (IFN-β), although its non-structural protein (NSs) could inhibit the induction of IFN-β if expressed in a heterologous context. A recombinant Rift Valley fever virus expressing the TOSV NSs could suppress IFN-β expression in infected cells. Moreover, in cells expressing NSs protein from a cDNA plasmid, IFN-β transcripts were not inducible by poly(I : C). Unlike other members of the family Bunyaviridae, TOSV appears to express an NSs protein that is a weak antagonist of IFN induction. Characterization of the interaction of TOSV with the IFN system will help our understanding of virus-host cell interactions and may explain why the pathogenesis of this disease is mostly mild in humans.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/10118
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