About thymic output, little is known in HIV-HCV co-infected patients. Thymic output can be measured by T-cell receptor excision circles (TREC) present in the so called "recent thymic emigrants" (RTEs). We have analyzed, by Real time PCR, sj-TREC+ cells in 11 patients with HIV-HCV co-infection; all patients were treated with highly active antiretroviral therapy (HAART), but were naive for interferon anti-HCV treatment. The results were compared with those of 21 age-matched normal donors. These data show no reduction of sj-TREC+ cells in co-infection. In 5 co-infected patients, IL-7 plasmatic levels were also evaluated by ELISA and no difference between co-infected patients and normal controls was found. Taken together, our data, although limited by the numerosity of the sample, may suggest that HCV co-infection does not affect the TREC/IL-7 pathway in HIV disease.
Cianci, R., DE LUCA, A., Cammarota, G., Cauda, R., Pandolfi, F. (2008). HCV co-infection does not affect the TREC/IL-7 pathway in HIV disease RID G-8810-2011. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 12(1), 67-69.
HCV co-infection does not affect the TREC/IL-7 pathway in HIV disease RID G-8810-2011
DE LUCA, ANDREA;
2008-01-01
Abstract
About thymic output, little is known in HIV-HCV co-infected patients. Thymic output can be measured by T-cell receptor excision circles (TREC) present in the so called "recent thymic emigrants" (RTEs). We have analyzed, by Real time PCR, sj-TREC+ cells in 11 patients with HIV-HCV co-infection; all patients were treated with highly active antiretroviral therapy (HAART), but were naive for interferon anti-HCV treatment. The results were compared with those of 21 age-matched normal donors. These data show no reduction of sj-TREC+ cells in co-infection. In 5 co-infected patients, IL-7 plasmatic levels were also evaluated by ELISA and no difference between co-infected patients and normal controls was found. Taken together, our data, although limited by the numerosity of the sample, may suggest that HCV co-infection does not affect the TREC/IL-7 pathway in HIV disease.
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https://hdl.handle.net/11365/1011730
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