Fifty-nine human immunodeficiency virus (HIV)-infected patients with suspected progressive multifocal leukoencephalopathy and 224 controls were tested for JC virus (JCV) DNA in cerebrospinal fluid by PCR. The diagnostic positive detection rate dropped from 89.5% (95% confidence intervals of 75.5 to 103.5%) in the pre-highly active antiretroviral therapy (HAART) era to 57.5% (95% confidence intervals of 42.1 to 72.9%) in the HAART era; the specificity remained unchanged. Predictors of failure to detect JCV DNA were exposure to HAART at disease onset and higher CD4 counts.

Marzocchetti, A., DI GIAMBENEDETTO, S., Cingolani, A., Ammassari, A., Cauda, R., DE LUCA, A. (2005). Reduced rate of diagnostic positive detection of JC virus DNA in cerebrospinal fluid in cases of suspected progressive multifocal leukoencephalopathy in the era of potent antiretroviral therapy. JOURNAL OF CLINICAL MICROBIOLOGY, 43(8), 4175-4177 [10.1128/JCM.43.8.4175-4177.2005].

Reduced rate of diagnostic positive detection of JC virus DNA in cerebrospinal fluid in cases of suspected progressive multifocal leukoencephalopathy in the era of potent antiretroviral therapy

DE LUCA A
2005-01-01

Abstract

Fifty-nine human immunodeficiency virus (HIV)-infected patients with suspected progressive multifocal leukoencephalopathy and 224 controls were tested for JC virus (JCV) DNA in cerebrospinal fluid by PCR. The diagnostic positive detection rate dropped from 89.5% (95% confidence intervals of 75.5 to 103.5%) in the pre-highly active antiretroviral therapy (HAART) era to 57.5% (95% confidence intervals of 42.1 to 72.9%) in the HAART era; the specificity remained unchanged. Predictors of failure to detect JCV DNA were exposure to HAART at disease onset and higher CD4 counts.
2005
Marzocchetti, A., DI GIAMBENEDETTO, S., Cingolani, A., Ammassari, A., Cauda, R., DE LUCA, A. (2005). Reduced rate of diagnostic positive detection of JC virus DNA in cerebrospinal fluid in cases of suspected progressive multifocal leukoencephalopathy in the era of potent antiretroviral therapy. JOURNAL OF CLINICAL MICROBIOLOGY, 43(8), 4175-4177 [10.1128/JCM.43.8.4175-4177.2005].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1011547