Increasing evidence indicates systemic inflammation as a new potential cause of acquired long QT syndrome (LQTS), via cytokine-mediated changes in cardiomyocyte ion channels. Torsade de pointes (TdP) is a life-threatening polymorphic ventricular tachycardia occurring in patients with LQTS, usually when multiple QT-prolonging factors are simultaneously present. Since classical risk factors cannot fully explain TdP events in a number of patients, we hypothesised that systemic inflammation may represent a currently overlooked risk factor contributing to TdP development in the general population.
|Titolo:||Systemic inflammation as a novel QT-prolonging risk factor in patients with torsades de pointes|
|Citazione:||Lazzerini, P.E., LAGHI PASINI, F., Bertolozzi, I., Morozzi, G., Lorenzini, S., Simpatico, A., et al. (2017). Systemic inflammation as a novel QT-prolonging risk factor in patients with torsades de pointes. HEART, 103(22), 1821-1829.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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