Is there a potential role for EGFR expression to lead margin reduction in glioblastoma?

We started to investigate a potential role for EGFR protein expression in predicting the modality of treatment failure in glioblastoma after Stupp protocol, in terms of both time-to-progression (TTP) and pattern of recurrence (PR) [central/in-field (C/I-F) vs. marginal/distant (M/D)]. EGFR expression is statistically correlated with TTP (log-rank test: p = 0.003) and PR (Fisher’s exact test: p = 0.01). Our results seem to suggest that EGFR expression might have a potential role for target contouring of RT volumes in GB patients that deserves further prospective investigations.