Background: T-cell lymphoblastic lymphoma comprises approximately 85-90% of all lymphoblastic lymphomas. It often arises as a mediastinal mass, and with bone marrow involvement. Presentation at other sites without nodal or mediastinal localization is uncommon. Case report: We describe clinical, histologic, immunohistochemical, and molecular features of two cases of primary T-cell lymphoblastic lymphoma arising respectively in uterine corpus and testis. The tumors were composed by medium to large cells, exhibiting a diffuse pattern of growth but sometimes forming indian files or pseudo-rosettes. The neoplastic cells strongly expressed TdT and T-cell markers in both uterine corpus and testis. However, the testis case also showed aberrant expression of B-cell markers, thus molecular biology was necessary to achieve a final diagnosis. T-cell receptor gene rearrangement analysis identified a T-cell origin. Conclusions: To the best of our knowledge, only one doubtful previous case of primary uterine T-cell lymphoblastic lymphoma and no previous cases of primary testicular T-cell lymphoblastic lymphoma have been reported. Due to the morphology of neoplastic cells, a challenging differential diagnosis with all the tumors belonging to the so-called small round blue cell tumor category is mandatory. In ambiguous lineage cases, molecular biology may represent an adequate tool to confirm diagnosis. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1559880973128230

Ambrosio, M.R., Onorati, M., Rocca, B.J., Ginori, A., Lobello, G., Petracco, G., et al. (2014). Unusual presentation of primary T-cell lymphoblastic lymphoma: Description of two cases. DIAGNOSTIC PATHOLOGY, 9 (Article Number 124), 1-6 [10.1186/1746-1596-9-124].

Unusual presentation of primary T-cell lymphoblastic lymphoma: Description of two cases

AMBROSIO, MARIA RAFFAELLA;ONORATI, MONICA;ROCCA, BRUNO JIM;GINORI, ALESSANDRO;VIDETTA, ALESSANDRO DAVIDE;LAZZI, STEFANO
2014-01-01

Abstract

Background: T-cell lymphoblastic lymphoma comprises approximately 85-90% of all lymphoblastic lymphomas. It often arises as a mediastinal mass, and with bone marrow involvement. Presentation at other sites without nodal or mediastinal localization is uncommon. Case report: We describe clinical, histologic, immunohistochemical, and molecular features of two cases of primary T-cell lymphoblastic lymphoma arising respectively in uterine corpus and testis. The tumors were composed by medium to large cells, exhibiting a diffuse pattern of growth but sometimes forming indian files or pseudo-rosettes. The neoplastic cells strongly expressed TdT and T-cell markers in both uterine corpus and testis. However, the testis case also showed aberrant expression of B-cell markers, thus molecular biology was necessary to achieve a final diagnosis. T-cell receptor gene rearrangement analysis identified a T-cell origin. Conclusions: To the best of our knowledge, only one doubtful previous case of primary uterine T-cell lymphoblastic lymphoma and no previous cases of primary testicular T-cell lymphoblastic lymphoma have been reported. Due to the morphology of neoplastic cells, a challenging differential diagnosis with all the tumors belonging to the so-called small round blue cell tumor category is mandatory. In ambiguous lineage cases, molecular biology may represent an adequate tool to confirm diagnosis. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1559880973128230
Ambrosio, M.R., Onorati, M., Rocca, B.J., Ginori, A., Lobello, G., Petracco, G., et al. (2014). Unusual presentation of primary T-cell lymphoblastic lymphoma: Description of two cases. DIAGNOSTIC PATHOLOGY, 9 (Article Number 124), 1-6 [10.1186/1746-1596-9-124].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1007141
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