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EnglishWe present a web interface which allows us to conveniently set up calculations based on the BioFET-SIM model. With the interface, the signal of a BioFET sensor can be calculated depending on its parameters, as well as the signal dependence on pH. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensitivity of the device. In the second case, the binding of an antibody/antigen complex on the nanowire surface is studied in terms of orientation and analyte/nanowire surface distance. We demonstrate how the BioFET-SIM web interface can aid in the understanding of experimental data and postulate alternative ways of antibody/antigen orientation on the nanowire surface. © 2012 Hediger et al.
Hediger, M.R., Jensen, J.H., & DE VICO, L. (2012). BioFET-SIM Web Interface: Implementation and Two Applications. PLOS ONE, 7(10), e45379.
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| Titolo: | BioFET-SIM Web Interface: Implementation and Two Applications |
| Autori: | |
| Rivista: | |
| Citazione: | Hediger, M.R., Jensen, J.H., & DE VICO, L. (2012). BioFET-SIM Web Interface: Implementation and Two Applications. PLOS ONE, 7(10), e45379. |
| Anno: | 2012 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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http://hdl.handle.net/11365/1006775
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