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EnglishWe report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.
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| Titolo: | Potential Antitumor Agents. 34. (1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-b]thiazoles and from Diimidazo[1,2-a:1,2-c]pyrimidine |
| Autori: | |
| Anno: | 2004 |
| Rivista: | |
| Abstract: | We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described. |
| Handle: | http://hdl.handle.net/11365/10050 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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