Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3]).

Arena, F., De Angelis, L.H., Cannatelli, A., DI PILATO, V., Amorese, M., D'Andrea, M.M., et al. (2016). Colistin resistance caused by inactivation of the MgrB regulator is not associated with decreased virulence of sequence type 258 KPC carbapenemase-producing Klebsiella pneumoniae. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(4), 2509-2512 [10.1128/AAC.02981-15].

Colistin resistance caused by inactivation of the MgrB regulator is not associated with decreased virulence of sequence type 258 KPC carbapenemase-producing Klebsiella pneumoniae

ARENA, FABIO;CANNATELLI, ANTONIO;DI PILATO, VINCENZO;D'ANDREA, MARCO MARIA;GIANI, TOMMASO;ROSSOLINI, GIAN MARIA
2016-01-01

Abstract

Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3]).
2016
Arena, F., De Angelis, L.H., Cannatelli, A., DI PILATO, V., Amorese, M., D'Andrea, M.M., et al. (2016). Colistin resistance caused by inactivation of the MgrB regulator is not associated with decreased virulence of sequence type 258 KPC carbapenemase-producing Klebsiella pneumoniae. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(4), 2509-2512 [10.1128/AAC.02981-15].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1001128
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo