A novel mcr variant, named mcr-1.2, encoding a Gln3-to-Leu functional variant of MCR-1, was detected in a KPC-3-producing ST512 Klebsiella pneumoniae isolate collected in Italy from a surveillance rectal swab from a leukemic child. The mcr-1.2 gene was carried on a transferable IncX4 plasmid whose structure was very similar to that of mcr-1-bearing plasmids previously found in Escherichia coli and K. pneumoniae strains from geographically distant sites (Estonia, China, and South Africa).

DI PILATO, V., Arena, F., Tascini, C., Cannatelli, A., HENRICI DE ANGELIS, L., Fortunato, S., et al. (2016). mcr-1.2, a new mcr variant carried on a transferable plasmid from a colistin-resistant KPC carbapenemase-producing Klebsiella pneumoniae strain of sequence type 512. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(9), 5612-5615 [10.1128/AAC.01075-16].

mcr-1.2, a new mcr variant carried on a transferable plasmid from a colistin-resistant KPC carbapenemase-producing Klebsiella pneumoniae strain of sequence type 512

DI PILATO, VINCENZO;ARENA, FABIO;CANNATELLI, ANTONIO;HENRICI DE ANGELIS, LUCIA;GIANI, TOMMASO;ROSSOLINI, GIAN MARIA
2016-01-01

Abstract

A novel mcr variant, named mcr-1.2, encoding a Gln3-to-Leu functional variant of MCR-1, was detected in a KPC-3-producing ST512 Klebsiella pneumoniae isolate collected in Italy from a surveillance rectal swab from a leukemic child. The mcr-1.2 gene was carried on a transferable IncX4 plasmid whose structure was very similar to that of mcr-1-bearing plasmids previously found in Escherichia coli and K. pneumoniae strains from geographically distant sites (Estonia, China, and South Africa).
2016
DI PILATO, V., Arena, F., Tascini, C., Cannatelli, A., HENRICI DE ANGELIS, L., Fortunato, S., et al. (2016). mcr-1.2, a new mcr variant carried on a transferable plasmid from a colistin-resistant KPC carbapenemase-producing Klebsiella pneumoniae strain of sequence type 512. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(9), 5612-5615 [10.1128/AAC.01075-16].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1001122
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