To assess the efficacy, tolerability and safety of Levetiracetam (LEV) therapy, we identified 21 (15 male; 6 female) patients with a history of benign epilepsy with centrotemporal spikes (BECTS), with and without secondarily generalization in children and adolescents aged between 5.0 and 12.1 years. LEV was administered as a first drug (number of patients=9) or converted after previous treatment with other AEDs (number of patients=12). The patients were subdivided into two groups: "newly diagnosed" patients and "converted" patients. Patients were followed up for 12 months and all patients were able to continue on LEV treatment. At the end of follow-up (12 months), all patients were seizure free or showed a reduction of seizures >50%. LEV dosage ranged from 1000 to 2500mg/daily. Overall, 100% of patients completed the 12 months study, without any important side effect. Somnolence and irritability occurred in two (9.5%) patients. Our results support findings that LEV monotherapy is effective and well tolerated in children with BECTS. Prospective, large, long-term double-blind studies are needed to confirm these findings.

Verrotti, A., Coppola, G., Manco, R., Ciambra, G., Iannetti, P., Grosso, S., et al. (2007). Levetiracetam monotherapy for children and adolescents with benign rolandic seizures. SEIZURE, 16(3), 271-275 [10.1016/j.seizure.2006.12.006].

Levetiracetam monotherapy for children and adolescents with benign rolandic seizures

Grosso, S.;Balestri, P.;
2007-01-01

Abstract

To assess the efficacy, tolerability and safety of Levetiracetam (LEV) therapy, we identified 21 (15 male; 6 female) patients with a history of benign epilepsy with centrotemporal spikes (BECTS), with and without secondarily generalization in children and adolescents aged between 5.0 and 12.1 years. LEV was administered as a first drug (number of patients=9) or converted after previous treatment with other AEDs (number of patients=12). The patients were subdivided into two groups: "newly diagnosed" patients and "converted" patients. Patients were followed up for 12 months and all patients were able to continue on LEV treatment. At the end of follow-up (12 months), all patients were seizure free or showed a reduction of seizures >50%. LEV dosage ranged from 1000 to 2500mg/daily. Overall, 100% of patients completed the 12 months study, without any important side effect. Somnolence and irritability occurred in two (9.5%) patients. Our results support findings that LEV monotherapy is effective and well tolerated in children with BECTS. Prospective, large, long-term double-blind studies are needed to confirm these findings.
2007
Verrotti, A., Coppola, G., Manco, R., Ciambra, G., Iannetti, P., Grosso, S., et al. (2007). Levetiracetam monotherapy for children and adolescents with benign rolandic seizures. SEIZURE, 16(3), 271-275 [10.1016/j.seizure.2006.12.006].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1000670
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