| Nome |
# |
|
Antibody drug conjugates (ADCs) charged with HDAC inhibitor for targeted epigenetic modulation, file e0feeaa7-9052-44d2-e053-6605fe0a8db0
|
214
|
|
Iron-Catalyzed Reductive Amination of Aldehydes in Isopropyl Alcohol/Water Media as Hydrogen Sources, file e0feeaa7-9054-44d2-e053-6605fe0a8db0
|
154
|
|
BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation, file e0feeaa6-258c-44d2-e053-6605fe0a8db0
|
153
|
|
Avoiding hot-spots in Microwave-Assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone, file e0feeaa8-2161-44d2-e053-6605fe0a8db0
|
141
|
|
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors, file e0feeaa8-2165-44d2-e053-6605fe0a8db0
|
119
|
|
Micellar catalysis for sustainable hydroformylation, file e0feeaaa-2265-44d2-e053-6605fe0a8db0
|
102
|
|
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases, file e0feeaab-4fe2-44d2-e053-6605fe0a8db0
|
58
|
|
Novel acylguanidine derivatives targeting smoothened induce antiproliferative and pro-apoptotic effects in chronic myeloid leukemia cells, file e0feeaa5-ad66-44d2-e053-6605fe0a8db0
|
56
|
|
Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma, file e0feeaaa-6551-44d2-e053-6605fe0a8db0
|
55
|
|
Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma, file e0feeaab-a2e3-44d2-e053-6605fe0a8db0
|
54
|
|
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway, file e0feeaa5-ad65-44d2-e053-6605fe0a8db0
|
53
|
|
The Antimalarial Mefloquine Shows Activity against Mycobacterium abscessus, Inhibiting Mycolic Acid Metabolism, file e0feeaaa-4965-44d2-e053-6605fe0a8db0
|
44
|
|
Antibody drug conjugates (ADCs) charged with HDAC inhibitor for targeted epigenetic modulation, file e0feeaa7-be3a-44d2-e053-6605fe0a8db0
|
41
|
|
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo, file e0feeaab-7da0-44d2-e053-6605fe0a8db0
|
31
|
|
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria, file e0feeaab-7408-44d2-e053-6605fe0a8db0
|
28
|
|
Synthesis of 1,2,3-substituted pyrroles from propargylamines via a one-pot tandem enyne cross metathesis-cyclization reaction, file e0feeaab-d41c-44d2-e053-6605fe0a8db0
|
25
|
|
A pH-responsive crosslinker platform for antibody-drug conjugate (ADC) targeting delivery, file 93bd6550-45f9-4de9-a8d2-266dd6aa9519
|
24
|
|
Continuous-Flow Palladium-Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source, file e0feeaab-bfe8-44d2-e053-6605fe0a8db0
|
24
|
|
An Intramolecular Hydroaminomethylation-Based Approach to Pyrrolizidine Alkaloids under Microwave-Assisted Heating, file 580dc65d-077b-446f-bcc8-abd0566b3fc2
|
17
|
|
Domino Hydrogenation-Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines, file e0feeaab-c384-44d2-e053-6605fe0a8db0
|
17
|
|
Design and synthesis of 1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethyl-octa-2,6-dienyl)-ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives: discovery of potent anti-tubercular agents effective against multi-drug resistant mycobacteria, file e0feeaab-7b05-44d2-e053-6605fe0a8db0
|
10
|
|
Microwave-assisted aminocabonylation of aryl bromides at low carbon monoxide pressure, file e0feeaa5-f4ef-44d2-e053-6605fe0a8db0
|
9
|
|
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis, file e0feeaab-7d16-44d2-e053-6605fe0a8db0
|
9
|
|
null, file 25bfcca4-6c61-41b1-b3b9-9c6a77ffcbb4
|
8
|
|
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo, file e0feeaa7-c851-44d2-e053-6605fe0a8db0
|
6
|
|
Design and synthesis of 1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethyl-octa-2,6-dienyl)-ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives: discovery of potent anti-tubercular agents effective against multi-drug resistant mycobacteria, file e0feeaa5-b617-44d2-e053-6605fe0a8db0
|
5
|
|
Structure and bioactive properties of novel textile dyes synthesised by fungal laccase, file e0feeaa8-dd52-44d2-e053-6605fe0a8db0
|
4
|
|
A highly stereo-controlled protocol to prepare pipecolic acids based on Heck and cyclohydrocarbonylation reactions, file e0feeaa5-7c8e-44d2-e053-6605fe0a8db0
|
3
|
|
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases, file e0feeaa6-4d93-44d2-e053-6605fe0a8db0
|
3
|
|
Chemical hybridization approaches applied to natural and synthetic compounds for the discovery of drugs active against neglected tropical diseases, file e0feeaa8-b121-44d2-e053-6605fe0a8db0
|
3
|
|
In Water Markovnikov Hydration and One-Pot Reductive Hydroamination of Terminal Alkynes under Ruthenium Nanoparticle Catalysis, file e0feeaa8-e47e-44d2-e053-6605fe0a8db0
|
3
|
|
Continuous-Flow Palladium-Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source, file e0feeaa9-ae6c-44d2-e053-6605fe0a8db0
|
3
|
|
MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor, file e0feeaa9-dfab-44d2-e053-6605fe0a8db0
|
3
|
|
Switching Mechanistic Pathways by Micellar Catalysis: A Highly Selective Rhodium Catalyst for the Hydroaminomethylation of Olefins with Anilines in Water, file ab60c989-da9f-47f9-be5e-c1debe5f9e6e
|
2
|
|
Synthesis of D- and L-2,3-trans-3,4-cis-4,5-trans-3,4-dihydroxy-5-hydroxymethylproline and tripeptides containing them, file e0feeaa4-bbbd-44d2-e053-6605fe0a8db0
|
2
|
|
Microwave-assisted intramolecular huisgen cycloaddition of azido alkynes derived from α-amino acids, file e0feeaa4-dba3-44d2-e053-6605fe0a8db0
|
2
|
|
Parallel solution phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines, file e0feeaa4-e631-44d2-e053-6605fe0a8db0
|
2
|
|
Domino Hydrogenation-Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines, file e0feeaa5-69cd-44d2-e053-6605fe0a8db0
|
2
|
|
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria, file e0feeaa6-5107-44d2-e053-6605fe0a8db0
|
2
|
|
Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities, file e0feeaa7-131b-44d2-e053-6605fe0a8db0
|
2
|
|
Iron-Catalyzed Reductive Amination of Aldehydes in Isopropyl Alcohol/Water Media as Hydrogen Sources, file e0feeaa7-bf9a-44d2-e053-6605fe0a8db0
|
2
|
|
An Effective and Reusable Hyperbranched Polymer Immobilized Rhodium Catalyst for the Hydroformylation of Olefins, file e0feeaa8-2e9c-44d2-e053-6605fe0a8db0
|
2
|
|
Novel textile dye obtained through transformation of 2-amino-3-methoxybenzoic acid by free and immobilised laccase from a Pleurotus ostreatus strain, file e0feeaa8-395b-44d2-e053-6605fe0a8db0
|
2
|
|
Synthesis of 1,2,3-substituted pyrroles from propargylamines via a one-pot tandem enyne cross metathesis-cyclization reaction, file e0feeaaa-4401-44d2-e053-6605fe0a8db0
|
2
|
|
A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria, file e0feeaab-0032-44d2-e053-6605fe0a8db0
|
2
|
|
Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA, file e0feeaab-86b1-44d2-e053-6605fe0a8db0
|
2
|
|
Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as a new ribella virus inhibitors, file e0feeaa4-e584-44d2-e053-6605fe0a8db0
|
1
|
|
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides, file e0feeaa4-e7db-44d2-e053-6605fe0a8db0
|
1
|
|
A general approach to substituted benzimidazoles and benzoxazoles via heterogeneous palladium catalyzed hydrogen transfer with primary amines, file e0feeaa4-f918-44d2-e053-6605fe0a8db0
|
1
|
|
Discovery, Molecular and Pharmacological Characterization
of GSA-10, a Novel Small-Molecule Positive Modulator
of Smoothened, file e0feeaa4-fde1-44d2-e053-6605fe0a8db0
|
1
|
|
null, file e0feeaa5-81c1-44d2-e053-6605fe0a8db0
|
1
|
|
TRYPTOPHAN-BASED LINEAR DIPEPTIDESAND 1,4-DIKETOPIPERAZINES AS SIMPLIFIED SCAFFOLD OF THE NATURAL CYCLOTETRAPEPTIDE FR235222, file e0feeaa5-dbb0-44d2-e053-6605fe0a8db0
|
1
|
|
Microwave Assisted Hydrogenation of Pyridinecarboxylates: a Convenient Access to Valuable Scaffolds for Diversity Oriented Synthesis, file e0feeaa5-e21c-44d2-e053-6605fe0a8db0
|
1
|
|
Microwaves make hydroformylation a rapid and easy process, file e0feeaa5-e921-44d2-e053-6605fe0a8db0
|
1
|
|
An improved synthesis of α,β-unsaturated nitrones relevant to the stephacidins and analogs thereof, file e0feeaa5-e934-44d2-e053-6605fe0a8db0
|
1
|
|
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis, file e0feeaa6-10e8-44d2-e053-6605fe0a8db0
|
1
|
|
Pd/C catalysis under microwave dielectric heating, file e0feeaa6-2b8b-44d2-e053-6605fe0a8db0
|
1
|
|
Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma, file e0feeaa6-ec96-44d2-e053-6605fe0a8db0
|
1
|
|
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities, file e0feeaa7-beaa-44d2-e053-6605fe0a8db0
|
1
|
|
Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents, file e0feeaa9-08d1-44d2-e053-6605fe0a8db0
|
1
|
|
Antibody drug conjugates with hydroxamic acid cargos for histone deacetylase (HDAC) inhibition, file e0feeaa9-7999-44d2-e053-6605fe0a8db0
|
1
|
|
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth, file e2a53d33-0fac-4f32-b4d3-5ad6d24f88c1
|
1
|
| Totale |
1.521 |