DE LUCA, FILOMENA
DE LUCA, FILOMENA
Dipartimento di Biotecnologie Mediche
1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors
2022-01-01 Verdirosa, Federica; Gavara, Laurent; Sevaille, Laurent; Tassone, Giusy; Corsica, Giuseppina; Legru, Alice; Feller, Georges; Chelini, Giulia; Mercuri, Paola Sandra; Tanfoni, Silvia; Sannio, Filomena; Benvenuti, Manuela; Cerboni, Giulia; De Luca, Filomena; Bouajila, Ezeddine; Vo Hoang, Yen; Licznar-Fajardo, Patricia; Galleni, Moreno; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Hernandez, Jean-François
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors
2022-01-01 Gavara, Laurent; Verdirosa, Federica; Sevaille, Laurent; Legru, Alice; Corsica, Giuseppina; Nauton, Lionel; Sandra Mercuri, Paola; Sannio, Filomena; De Luca, Filomena; Hadjadj, Margot; Cerboni, Giulia; Vo Hoang, Yen; Licznar-Fajardo, Patricia; Galleni, Moreno; Docquier, Jean-Denis; Hernandez, Jean-François
1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-β-lactamases
2017-01-01 Sevaille, Laurent; Gavara, Laurent; Bebrone, Carine; DE LUCA, Filomena; Nauton, Lionel; Achard, Maud; Mercuri, Paola; Tanfoni, Silvia; Borgianni, Luisa; Guyon, Carole; Lonjon, Pauline; Turan Zitouni, Gülhan; Dzieciolowski, Julia; Becker, Katja; Bénard, Lionel; Condon, Ciaran; Maillard, Ludovic; Martinez, Jean; Frère, Jean Marie; Dideberg, Otto; Galleni, Moreno; Docquier, JEAN DENIS; Hernandez, Jean François
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors
2021-01-01 Gavara, Laurent; Legru, Alice; Verdirosa, Federica; Sevaille, Laurent; Nauton, Lionel; Corsica, Giuseppina; Mercuri, Paola Sandra; Sannio, Filomena; Feller, Georges; Coulon, Rémi; De Luca, Filomena; Cerboni, Giulia; Tanfoni, Silvia; Chelini, Giulia; Galleni, Moreno; Docquier, Jean-Denis; Hernandez, Jean-François
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors
2020-01-01 Gavara, L.; Sevaille, L.; De Luca, F.; Mercuri, P.; Bebrone, C.; Feller, G.; Legru, A.; Cerboni, G.; Tanfoni, S.; Baud, D.; Cutolo, G.; Bestgen, B.; Chelini, G.; Verdirosa, F.; Sannio, F.; Pozzi, C.; Benvenuti, M.; Kwapien, K.; Fischer, M.; Becker, K.; Frere, J. -M.; Mangani, S.; Gresh, N.; Berthomieu, D.; Galleni, M.; Docquier, Jd; Hernandez, J. -F.
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization
2018-01-01 Pasero, Carolina; D'Agostino, Ilaria; De Luca, Filomena; Zamperini, Claudio; Deodato, Davide; Truglio, Giuseppina I.; Sannio, Filomena; DEL PRETE, Rosita; Ferraro, Teresa; Visaggio, Daniela; Mancini, Arianna; Guglielmi, Mario B.; Visca, Paolo; Docquier, Jean-Denis; Botta, Maurizio
Amino acid replacement at position 228 induces fluctuation in the Ω-loop of KPC-3 and reduces the affinity against oxyimino cephalosporins: Kinetic and molecular dynamics studies
2020-01-01 Piccirilli, A.; Brisdelli, F.; Docquier, J. D.; Aschi, M.; Cherubini, S.; De Luca, F.; Matagne, A.; Amicosante, G.; Perilli, M.
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam
2018-01-01 Pozzi, Cecilia; Di Pisa, Flavio; De Luca, Filomena; Benvenuti, Manuela; Docquier, Jean Denis; Mangani, Stefano
Biochemical characterization of the POM-1 metallo-β-lactamase from Pseudomonas otitidis
2015-01-01 Borgianni, Luisa; DE LUCA, Filomena; Thaller, Maria Cristina; Chong, Yunsop; Rossolini, GIAN MARIA; Docquier, JEAN DENIS
Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece
2015-01-01 Papagiannitsis, Costas C; Pollini, Simona; DE LUCA, Filomena; Rossolini, GIAN MARIA; Docquier, JEAN DENIS; Hrabák, Jaroslav
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design
2018-01-01 Di Pisa, Flavio; Pozzi, Cecilia; Benvenuti, Manuela; Docquier, Jean-Denis; De Luca, Filomena; Mangani, Stefano
Characterization of a Functional Metallo-β-Lactamase from the Marine Bacterium Haliangium ochraceum
2015-01-01 Bianciardi, Simone; Borgianni, Luisa; DE LUCA, Filomena; Rossolini, GIAN MARIA; Docquier, JEAN DENIS
Chryseobacterium gleum in a man with prostatectomy in Senegal: A case report and review of the literature
2017-01-01 Arouna, O; DE LUCA, Filomena; Camara, M.; Fall, B.; Fall, B.; Ba Diallo, A.; Docquier, JEAN DENIS; Mboup, S.
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases
2017-01-01 Santucci, Matteo; Spyrakis, Francesca; Cross, Simon; Quotadamo, Antonio; Farina, Davide; Tondi, Donatella; De Luca, Filomena; Docquier, Jean-Denis; Prieto, Ana Isabel; Ibacache, Claudia; Blázquez, Jesús; Venturelli, Alberto; Cruciani, Gabriele; Costi, Maria Paola
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam.
2013-01-01 Pozzi, Cecilia; DE LUCA, Filomena; Benvenuti, Manuela; Poirel, L.; Rossolini, GIAN MARIA; Mangani, Stefano; Docquier, JEAN DENIS
Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates
2010-01-01 Docquier, JEAN DENIS; Benvenuti, Manuela; Calderone, V; Giuliani, F; Kapetis, D; DE LUCA, Filomena; Rossolini, GIAN MARIA; Mangani, Stefano
Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases
2009-01-01 Docquier, J. D.; Calderone, V.; De Luca, F.; Benvenuti, M.; Giuliani, F.; Bellucci, L.; Tafi, A.; Nordmann, P.; Botta, M.; Rossolini, G. M.; Mangani, S.
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem
2016-01-01 Pozzi, Cecilia; DE LUCA, Filomena; Benvenuti, Manuela; Poirel, Laurent; Nordmann, Patrice; Rossolini, GIAN MARIA; Mangani, Stefano; Docquier, JEAN DENIS
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol
2017-01-01 Maccari, Giorgio; Deodato, Davide; Fiorucci, Diego; Orofino, Francesco; Truglio, Giuseppina I.; Pasero, Carolina; Martini, Riccardo; De Luca, Filomena; Docquier, Jean-Denis; Botta, Maurizio
Discovery of a Novel Metallo-β-Lactamase Inhibitor that Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae
2018-01-01 Everett, Martin; Sprynski, Nicolas; Coelho, Alicia; Castandet, Jérôme; Bayet, Maëlle; Bougnon, Juliette; Lozano, Clarisse; Davies, David T; Leiris, Simon; Zalacain, Magdalena; Morrissey, Ian; Magnet, Sophie; Holden, Kirsty; Warn, Peter; De Luca, Filomena; Docquier, Jean-Denis; Lemonnier, Marc
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors | 1-gen-2022 | Verdirosa, Federica; Gavara, Laurent; Sevaille, Laurent; Tassone, Giusy; Corsica, Giuseppina; Legru, Alice; Feller, Georges; Chelini, Giulia; Mercuri, Paola Sandra; Tanfoni, Silvia; Sannio, Filomena; Benvenuti, Manuela; Cerboni, Giulia; De Luca, Filomena; Bouajila, Ezeddine; Vo Hoang, Yen; Licznar-Fajardo, Patricia; Galleni, Moreno; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Hernandez, Jean-François | - | |
| 1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors | 1-gen-2022 | Gavara, Laurent; Verdirosa, Federica; Sevaille, Laurent; Legru, Alice; Corsica, Giuseppina; Nauton, Lionel; Sandra Mercuri, Paola; Sannio, Filomena; De Luca, Filomena; Hadjadj, Margot; Cerboni, Giulia; Vo Hoang, Yen; Licznar-Fajardo, Patricia; Galleni, Moreno; Docquier, Jean-Denis; Hernandez, Jean-François | - | |
| 1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-β-lactamases | 1-gen-2017 | Sevaille, Laurent; Gavara, Laurent; Bebrone, Carine; DE LUCA, Filomena; Nauton, Lionel; Achard, Maud; Mercuri, Paola; Tanfoni, Silvia; Borgianni, Luisa; Guyon, Carole; Lonjon, Pauline; Turan Zitouni, Gülhan; Dzieciolowski, Julia; Becker, Katja; Bénard, Lionel; Condon, Ciaran; Maillard, Ludovic; Martinez, Jean; Frère, Jean Marie; Dideberg, Otto; Galleni, Moreno; Docquier, JEAN DENIS; Hernandez, Jean François | - | |
| 4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors | 1-gen-2021 | Gavara, Laurent; Legru, Alice; Verdirosa, Federica; Sevaille, Laurent; Nauton, Lionel; Corsica, Giuseppina; Mercuri, Paola Sandra; Sannio, Filomena; Feller, Georges; Coulon, Rémi; De Luca, Filomena; Cerboni, Giulia; Tanfoni, Silvia; Chelini, Giulia; Galleni, Moreno; Docquier, Jean-Denis; Hernandez, Jean-François | - | |
| 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors | 1-gen-2020 | Gavara, L.; Sevaille, L.; De Luca, F.; Mercuri, P.; Bebrone, C.; Feller, G.; Legru, A.; Cerboni, G.; Tanfoni, S.; Baud, D.; Cutolo, G.; Bestgen, B.; Chelini, G.; Verdirosa, F.; Sannio, F.; Pozzi, C.; Benvenuti, M.; Kwapien, K.; Fischer, M.; Becker, K.; Frere, J. -M.; Mangani, S.; Gresh, N.; Berthomieu, D.; Galleni, M.; Docquier, Jd; Hernandez, J. -F. | - | |
| Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization | 1-gen-2018 | Pasero, Carolina; D'Agostino, Ilaria; De Luca, Filomena; Zamperini, Claudio; Deodato, Davide; Truglio, Giuseppina I.; Sannio, Filomena; DEL PRETE, Rosita; Ferraro, Teresa; Visaggio, Daniela; Mancini, Arianna; Guglielmi, Mario B.; Visca, Paolo; Docquier, Jean-Denis; Botta, Maurizio | - | |
| Amino acid replacement at position 228 induces fluctuation in the Ω-loop of KPC-3 and reduces the affinity against oxyimino cephalosporins: Kinetic and molecular dynamics studies | 1-gen-2020 | Piccirilli, A.; Brisdelli, F.; Docquier, J. D.; Aschi, M.; Cherubini, S.; De Luca, F.; Matagne, A.; Amicosante, G.; Perilli, M. | - | |
| Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam | 1-gen-2018 | Pozzi, Cecilia; Di Pisa, Flavio; De Luca, Filomena; Benvenuti, Manuela; Docquier, Jean Denis; Mangani, Stefano | - | |
| Biochemical characterization of the POM-1 metallo-β-lactamase from Pseudomonas otitidis | 1-gen-2015 | Borgianni, Luisa; DE LUCA, Filomena; Thaller, Maria Cristina; Chong, Yunsop; Rossolini, GIAN MARIA; Docquier, JEAN DENIS | - | |
| Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece | 1-gen-2015 | Papagiannitsis, Costas C; Pollini, Simona; DE LUCA, Filomena; Rossolini, GIAN MARIA; Docquier, JEAN DENIS; Hrabák, Jaroslav | - | |
| Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design | 1-gen-2018 | Di Pisa, Flavio; Pozzi, Cecilia; Benvenuti, Manuela; Docquier, Jean-Denis; De Luca, Filomena; Mangani, Stefano | - | |
| Characterization of a Functional Metallo-β-Lactamase from the Marine Bacterium Haliangium ochraceum | 1-gen-2015 | Bianciardi, Simone; Borgianni, Luisa; DE LUCA, Filomena; Rossolini, GIAN MARIA; Docquier, JEAN DENIS | - | |
| Chryseobacterium gleum in a man with prostatectomy in Senegal: A case report and review of the literature | 1-gen-2017 | Arouna, O; DE LUCA, Filomena; Camara, M.; Fall, B.; Fall, B.; Ba Diallo, A.; Docquier, JEAN DENIS; Mboup, S. | - | |
| Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases | 1-gen-2017 | Santucci, Matteo; Spyrakis, Francesca; Cross, Simon; Quotadamo, Antonio; Farina, Davide; Tondi, Donatella; De Luca, Filomena; Docquier, Jean-Denis; Prieto, Ana Isabel; Ibacache, Claudia; Blázquez, Jesús; Venturelli, Alberto; Cruciani, Gabriele; Costi, Maria Paola | - | |
| Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. | 1-gen-2013 | Pozzi, Cecilia; DE LUCA, Filomena; Benvenuti, Manuela; Poirel, L.; Rossolini, GIAN MARIA; Mangani, Stefano; Docquier, JEAN DENIS | - | |
| Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates | 1-gen-2010 | Docquier, JEAN DENIS; Benvenuti, Manuela; Calderone, V; Giuliani, F; Kapetis, D; DE LUCA, Filomena; Rossolini, GIAN MARIA; Mangani, Stefano | - | |
| Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases | 1-gen-2009 | Docquier, J. D.; Calderone, V.; De Luca, F.; Benvenuti, M.; Giuliani, F.; Bellucci, L.; Tafi, A.; Nordmann, P.; Botta, M.; Rossolini, G. M.; Mangani, S. | - | |
| Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem | 1-gen-2016 | Pozzi, Cecilia; DE LUCA, Filomena; Benvenuti, Manuela; Poirel, Laurent; Nordmann, Patrice; Rossolini, GIAN MARIA; Mangani, Stefano; Docquier, JEAN DENIS | - | |
| Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol | 1-gen-2017 | Maccari, Giorgio; Deodato, Davide; Fiorucci, Diego; Orofino, Francesco; Truglio, Giuseppina I.; Pasero, Carolina; Martini, Riccardo; De Luca, Filomena; Docquier, Jean-Denis; Botta, Maurizio | - | |
| Discovery of a Novel Metallo-β-Lactamase Inhibitor that Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae | 1-gen-2018 | Everett, Martin; Sprynski, Nicolas; Coelho, Alicia; Castandet, Jérôme; Bayet, Maëlle; Bougnon, Juliette; Lozano, Clarisse; Davies, David T; Leiris, Simon; Zalacain, Magdalena; Morrissey, Ian; Magnet, Sophie; Holden, Kirsty; Warn, Peter; De Luca, Filomena; Docquier, Jean-Denis; Lemonnier, Marc | - |