Sfoglia per Autore
Design, synthesis and in vitro experimental validation of novel TRPV4 antagonists inspired by labdane diterpenes
2020-01-01 Mazzotta, S.; Carullo, G.; Schiano Moriello, A.; Amodeo, P.; Di Marzo, V.; Vega-Holm, M.; Vitale, R. M.; Aiello, F.; Brizzi, A.; De Petrocellis, L.
Targeting neuropathic pain: pathobiology, current treatment and peptidomimetics as a new therapeutic opportunity
2020-01-01 Caroleo, M. C.; Brizzi, A.; De Rosa, M.; Pandey, A.; Gallelli, L.; Badolato, M.; Carullo, G.; Cione, E.
Cytotoxic effects of cannabinoids on human HT-29 colorectal adenocarcinoma cells: different mechanisms of THC, CBD, and CB83
2020-01-01 Cerretani, Daniela; Collodel, Giulia; Brizzi, Antonella; Fiaschi, ANNA IDA; Menchiari, Andrea; Moretti, Elena; Moltoni, Laura; Micheli, Lucia
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators
2020-01-01 Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico
The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives
2020-01-01 Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; M Paola, Castelli; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity
2020-01-01 Mugnaini, C.; Sannio, F.; Brizzi, A.; Del Prete, R.; Simone, T.; Ferraro, T.; De Luca, F.; Corelli, F.; Docquier, J. D.
New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands
2020-01-01 Mugnaini, Claudia; Brizzi, Antonella; Vinciarelli, Giorgia; Paolino, Marco; Corelli, Federico
Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo
2020-01-01 Mugnaini, Claudia; Kostrzewa, Magdalena; Bryk, Marta; Mokhtar Mahmoud, Ali; Brizzi, Antonella; Lamponi, Stefania; Giorgi, Gianluca; Ferlenghi, Francesca; Vacondio, Federica; Maccioni, Paola; Colombo, Giancarlo; Mor, Marco; Starowicz, Katarzyna; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico
Old strategies and new perspectives in modulating the endocannabinoid system
2019-01-01 Brizzi, Antonella; Pessina, Federica
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease
2019-01-01 Mugnaini, Claudia; Rabbito, Alessandro; Brizzi, Antonella; Palombi, Nastasja; Petrosino, Stefania; Verde, Roberta; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico
Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues
2019-01-01 Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Fara, Federica; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico
Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators
2017-01-01 Badolato, Mariateresa; Carullo, Gabriele; Perri, Mariarita; Cione, Erika; Manetti, Fabrizio; Di Gioia, Maria Luisa; Brizzi, Antonella; Caroleo, Maria Cristina; Aiello, Francesca
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors
2017-01-01 Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Zaru, Alessandro; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico
TRPV1-FAAH-COX: The Couples Game in Pain Treatment
2016-01-01 Aiello, Francesca; Carullo, Gabriele; Badolato, Mariateresa; Brizzi, Antonella
Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress
2016-01-01 Aiello, F.; Badolato, M.; Pessina, Federica; Sticozzi, C.; Maestrini, Vanessa; Aldinucci, C.; Luongo, L.; Guida, F.; Ligresti, A.; Artese, A.; Allarà, M.; Costa, G.; Frosini, Maria; Schiano Morello, A.; De Petrocellis, L.; Valacchi, G.; Alcaro, S.; Maione, S.; Di Marzo, V.; Corelli, Federico; Brizzi, Antonella
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility
2016-01-01 Mugnaini, Claudia; Brizzi, Antonella; Ligresti, Alessia; Allarà, Marco; Lamponi, Stefania; Vacondio, Federica; Silva, Claudia; Mor, Marco; Di Marzo, Vincenzo; Corelli, Federico
Ligandi TRPV1
2014-01-01 Brizzi, Antonella; Corelli, Federico; Aiello, Francesca
Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist
2014-01-01 Brizzi, Antonella; Aiello, Francesca; Marini, Pietro; Cascio, Maria Grazia; Corelli, Federico; Brizzi, Vittorio; De Petrocellis, Luciano; Ligresti, Alessia; Luongo, Livio; Lamponi, Stefania; Maione, Sabatino; Pertwee, Roger G.; Di Marzo, Vincenzo
Active manganese dioxide promoted cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids to 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one derivatives
2013-01-01 Fedora, Grande; Brizzi, Antonella; Garofalo, Antonio; Francesca, Aiello
New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains
2013-01-01 Guerrini, Valentina; De Rosa, M.; Pasquini, S.; Mugnaini, Claudia; Brizzi, Antonella; Cuppone, Anna Maria; Pozzi, Gianni; Corelli, Federico
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Design, synthesis and in vitro experimental validation of novel TRPV4 antagonists inspired by labdane diterpenes | 1-gen-2020 | Mazzotta, S.; Carullo, G.; Schiano Moriello, A.; Amodeo, P.; Di Marzo, V.; Vega-Holm, M.; Vitale, R. M.; Aiello, F.; Brizzi, A.; De Petrocellis, L. | - | |
| Targeting neuropathic pain: pathobiology, current treatment and peptidomimetics as a new therapeutic opportunity | 1-gen-2020 | Caroleo, M. C.; Brizzi, A.; De Rosa, M.; Pandey, A.; Gallelli, L.; Badolato, M.; Carullo, G.; Cione, E. | - | |
| Cytotoxic effects of cannabinoids on human HT-29 colorectal adenocarcinoma cells: different mechanisms of THC, CBD, and CB83 | 1-gen-2020 | Cerretani, Daniela; Collodel, Giulia; Brizzi, Antonella; Fiaschi, ANNA IDA; Menchiari, Andrea; Moretti, Elena; Moltoni, Laura; Micheli, Lucia | - | |
| Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators | 1-gen-2020 | Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico | - | |
| The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives | 1-gen-2020 | Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; M Paola, Castelli; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico | - | |
| Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity | 1-gen-2020 | Mugnaini, C.; Sannio, F.; Brizzi, A.; Del Prete, R.; Simone, T.; Ferraro, T.; De Luca, F.; Corelli, F.; Docquier, J. D. | - | |
| New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands | 1-gen-2020 | Mugnaini, Claudia; Brizzi, Antonella; Vinciarelli, Giorgia; Paolino, Marco; Corelli, Federico | - | |
| Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo | 1-gen-2020 | Mugnaini, Claudia; Kostrzewa, Magdalena; Bryk, Marta; Mokhtar Mahmoud, Ali; Brizzi, Antonella; Lamponi, Stefania; Giorgi, Gianluca; Ferlenghi, Francesca; Vacondio, Federica; Maccioni, Paola; Colombo, Giancarlo; Mor, Marco; Starowicz, Katarzyna; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico | - | |
| Old strategies and new perspectives in modulating the endocannabinoid system | 1-gen-2019 | Brizzi, Antonella; Pessina, Federica | - | |
| Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease | 1-gen-2019 | Mugnaini, Claudia; Rabbito, Alessandro; Brizzi, Antonella; Palombi, Nastasja; Petrosino, Stefania; Verde, Roberta; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico | - | |
| Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues | 1-gen-2019 | Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Fara, Federica; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico | - | |
| Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators | 1-gen-2017 | Badolato, Mariateresa; Carullo, Gabriele; Perri, Mariarita; Cione, Erika; Manetti, Fabrizio; Di Gioia, Maria Luisa; Brizzi, Antonella; Caroleo, Maria Cristina; Aiello, Francesca | - | |
| Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors | 1-gen-2017 | Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Zaru, Alessandro; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico | - | |
| TRPV1-FAAH-COX: The Couples Game in Pain Treatment | 1-gen-2016 | Aiello, Francesca; Carullo, Gabriele; Badolato, Mariateresa; Brizzi, Antonella | - | |
| Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress | 1-gen-2016 | Aiello, F.; Badolato, M.; Pessina, Federica; Sticozzi, C.; Maestrini, Vanessa; Aldinucci, C.; Luongo, L.; Guida, F.; Ligresti, A.; Artese, A.; Allarà, M.; Costa, G.; Frosini, Maria; Schiano Morello, A.; De Petrocellis, L.; Valacchi, G.; Alcaro, S.; Maione, S.; Di Marzo, V.; Corelli, Federico; Brizzi, Antonella | - | |
| Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility | 1-gen-2016 | Mugnaini, Claudia; Brizzi, Antonella; Ligresti, Alessia; Allarà, Marco; Lamponi, Stefania; Vacondio, Federica; Silva, Claudia; Mor, Marco; Di Marzo, Vincenzo; Corelli, Federico | - | |
| Ligandi TRPV1 | 1-gen-2014 | Brizzi, Antonella; Corelli, Federico; Aiello, Francesca | - | |
| Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist | 1-gen-2014 | Brizzi, Antonella; Aiello, Francesca; Marini, Pietro; Cascio, Maria Grazia; Corelli, Federico; Brizzi, Vittorio; De Petrocellis, Luciano; Ligresti, Alessia; Luongo, Livio; Lamponi, Stefania; Maione, Sabatino; Pertwee, Roger G.; Di Marzo, Vincenzo | - | |
| Active manganese dioxide promoted cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids to 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one derivatives | 1-gen-2013 | Fedora, Grande; Brizzi, Antonella; Garofalo, Antonio; Francesca, Aiello | - | |
| New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains | 1-gen-2013 | Guerrini, Valentina; De Rosa, M.; Pasquini, S.; Mugnaini, Claudia; Brizzi, Antonella; Cuppone, Anna Maria; Pozzi, Gianni; Corelli, Federico | - |
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