Sfoglia per Autore
Intermolecular interactions of the extended recognition site of VIM-2 metallo-β-lactamase with 1,2,4-triazole-3-thione inhibitors. Validations of a polarizable molecular mechanics potential by ab initio QC
2021-01-01 Kwapien, K.; Gavara, L.; Docquier, J. D.; Berthomieu, D.; Hernandez, J. -F.; Gresh, N.
Efficient inactivation of sars-cov-2 and other rna or dna viruses with blue led light
2021-01-01 Terrosi, C.; Anichini, G.; Docquier, J. D.; Savellini, G. G.; Gandolfo, C.; Pavone, F. S.; Cusi, M. G.
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity
2021-01-01 Legru, Alice; Verdirosa, Federica; Hernandez, Jean-François; Tassone, Giusy; Sannio, Filomena; Benvenuti, Manuela; Conde, Pierre-Alexis; Bossis, Guillaume; Thomas, Caitlyn A; Crowder, Michael W; Dillenberger, Melissa; Becker, Katja; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Gavara, Laurent
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
2020-01-01 Liu, B.; Trout, R. E. L.; Chu, G. -H.; Mcgarry, D.; Jackson, R. W.; Hamrick, J. C.; Daigle, D. M.; Cusick, S. M.; Pozzi, C.; De Luca, F.; Benvenuti, M.; Mangani, S.; Docquier, J. -D.; Weiss, W. J.; Pevear, D. C.; Xerri, L.; Burns, C. J.
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa
2020-01-01 Hamrick, J. C.; Docquier, J. -D.; Uehara, T.; Myers, C. L.; Six, D. A.; Chatwin, C. L.; John, K. J.; Vernacchio, S. F.; Cusick, S. M.; Trout, R. E. L.; Pozzi, C.; De Luca, F.; Benvenuti, M.; Mangani, S.; Liu, B.; Jackson, R. W.; Moeck, G.; Xerri, L.; Burns, C. J.; Pevear, D. C.; Daigle, D. M.
Screen of Unfocused Libraries Identified Compounds with Direct or Synergistic Antibacterial Activity
2020-01-01 Mugnaini, C.; Sannio, F.; Brizzi, A.; Del Prete, R.; Simone, T.; Ferraro, T.; De Luca, F.; Corelli, F.; Docquier, J. D.
ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae
2020-01-01 Davies, D. T.; Leiris, S.; Sprynski, N.; Castandet, J.; Lozano, C.; Bousquet, J.; Zalacain, M.; Vasa, S.; Dasari, P. K.; Pattipati, R.; Vempala, N.; Gujjewar, S.; Godi, S.; Jallala, R.; Sathyap, R. R.; Darshanoju, N. A.; Ravu, V. R.; Juventhala, R. R.; Pottabathini, N.; Sharma, S.; Pothukanuri, S.; Holden, K.; Warn, P.; Marcoccia, F.; Benvenuti, M.; Pozzi, C.; Mangani, S.; Docquier, J. D.; Lemonnier, M.; Everett, M.
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors
2020-01-01 Gavara, L.; Sevaille, L.; De Luca, F.; Mercuri, P.; Bebrone, C.; Feller, G.; Legru, A.; Cerboni, G.; Tanfoni, S.; Baud, D.; Cutolo, G.; Bestgen, B.; Chelini, G.; Verdirosa, F.; Sannio, F.; Pozzi, C.; Benvenuti, M.; Kwapien, K.; Fischer, M.; Becker, K.; Frere, J. -M.; Mangani, S.; Gresh, N.; Berthomieu, D.; Galleni, M.; Docquier, Jd; Hernandez, J. -F.
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases
2020-01-01 Spyrakis, F.; Santucci, M.; Maso, L.; Cross, S.; Gianquinto, E.; Sannio, F.; Verdirosa, F.; De Luca, F.; Docquier, J. D.; Cendron, L.; Tondi, D.; Venturelli, A.; Cruciani, G.; Costi, M. P.
Isonitrile-based multicomponent synthesis of β-amino boronic acids as β-lactamase inhibitors
2020-01-01 Bassini, E.; Gazzotti, S.; Sannio, F.; Presti, L. L.; Sgrignani, J.; Docquier, J. D.; Grazioso, G.; Silvani, A.
A standard numbering scheme for class C β-lactamases
2020-01-01 Mack, A. R.; Barnes, M. D.; Taracila, M. A.; Hujer, A. M.; Hujer, K. M.; Cabot, G.; Feldgarden, M.; Haft, D. H.; Klimke, W.; Van Den Akker, F.; Vila, A. J.; Smania, A.; Haider, S.; Papp-Wallace, K. M.; Bradford, P. A.; Rossolini, G. M.; Docquier, J. D.; Frere, J. -M.; Galleni, M.; Hanson, N. D.; Oliver, A.; Plesiat, P.; Poirel, L.; Nordmann, P.; Palzkill, T. G.; Jacoby, G. A.; Bush, K.; Bonomo, R. A.
Amino acid replacement at position 228 induces fluctuation in the Ω-loop of KPC-3 and reduces the affinity against oxyimino cephalosporins: Kinetic and molecular dynamics studies
2020-01-01 Piccirilli, A.; Brisdelli, F.; Docquier, J. D.; Aschi, M.; Cherubini, S.; De Luca, F.; Matagne, A.; Amicosante, G.; Perilli, M.
4-(N-alkyl-and-acyl-amino)-1,2,4-triazole-3-thione analogs as metallo-β-lactamase inhibitors: Impact of 4-linker on potency and spectrum of inhibition
2020-01-01 Gavara, L.; Verdirosa, F.; Legru, A.; Mercuri, P. S.; Nauton, L.; Sevaille, L.; Feller, G.; Berthomieu, D.; Sannio, F.; Marcoccia, F.; Tanfoni, S.; Luca, F. D.; Gresh, N.; Galleni, M.; Docquier, J. D.; Hernandez, J. -F.
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii
2020-01-01 Davies, D. T.; Leiris, S.; Zalacain, M.; Sprynski, N.; Castandet, J.; Bousquet, J.; Lozano, C.; Llanos, A.; Alibaud, L.; Vasa, S.; Pattipati, R.; Valige, R.; Kummari, B.; Pothukanuri, S.; De Piano, C.; Morrissey, I.; Holden, K.; Warn, P.; Marcoccia, F.; Benvenuti, M.; Pozzi, C.; Tassone, G.; Mangani, S.; Docquier, J. D.; Pallin, D.; Elliot, R.; Lemonnier, M.; Everett, M.
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model
2019-01-01 Leiris, Simon; Coelho, Alicia; Castandet, Jérôme; Bayet, Maëlle; Lozano, Clarisse; Bougnon, Juliette; Bousquet, Justine; Everett, Martin; Lemonnier, Marc; Sprynski, Nicolas; Zalacain, Magdalena; Pallin, Thomas David; Cramp, Michael C.; Jennings, Neil; Raphy, Gilles; Jones, Mark W.; Pattipati, Ramesh; Shankar, Battu; Sivasubrahmanyam, Relangi; Soodhagani, Ashok K.; Juventhala, Ramakrishna R.; Pottabathini, Narender; Pothukanuri, Srinivasu; Benvenuti, Manuela; Pozzi, Cecilia; Mangani, Stefano; De Luca, Filomena; Cerboni, Giulia; Docquier, Jean-Denis; Davies, David T.
Deciphering multifactorial resistance phenotypes in acinetobacter baumannii by genomics and targeted label-free proteomics
2018-01-01 Cecchini, Tiphaine; Yoon, Eun-Jeong; Charretier, Yannick; Bardet, Chloé; Beaulieu, Corinne; Lacoux, Xavier; Docquier, Jean-Denis; Lemoine, Jerome; Courvalin, Patrice; Grillot-Courvalin, Catherine; Charrier, Jean-Philippe
An update on β-lactamase inhibitor discovery and development
2018-01-01 Docquier, Jean-Denis; Mangani, Stefano
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization
2018-01-01 Pasero, Carolina; D'Agostino, Ilaria; De Luca, Filomena; Zamperini, Claudio; Deodato, Davide; Truglio, Giuseppina I.; Sannio, Filomena; DEL PRETE, Rosita; Ferraro, Teresa; Visaggio, Daniela; Mancini, Arianna; Guglielmi, Mario B.; Visca, Paolo; Docquier, Jean-Denis; Botta, Maurizio
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design
2018-01-01 Di Pisa, Flavio; Pozzi, Cecilia; Benvenuti, Manuela; Docquier, Jean-Denis; De Luca, Filomena; Mangani, Stefano
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam
2018-01-01 Pozzi, Cecilia; Di Pisa, Flavio; De Luca, Filomena; Benvenuti, Manuela; Docquier, Jean Denis; Mangani, Stefano
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Intermolecular interactions of the extended recognition site of VIM-2 metallo-β-lactamase with 1,2,4-triazole-3-thione inhibitors. Validations of a polarizable molecular mechanics potential by ab initio QC | 1-gen-2021 | Kwapien, K.; Gavara, L.; Docquier, J. D.; Berthomieu, D.; Hernandez, J. -F.; Gresh, N. | - | |
| Efficient inactivation of sars-cov-2 and other rna or dna viruses with blue led light | 1-gen-2021 | Terrosi, C.; Anichini, G.; Docquier, J. D.; Savellini, G. G.; Gandolfo, C.; Pavone, F. S.; Cusi, M. G. | - | |
| 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity | 1-gen-2021 | Legru, Alice; Verdirosa, Federica; Hernandez, Jean-François; Tassone, Giusy; Sannio, Filomena; Benvenuti, Manuela; Conde, Pierre-Alexis; Bossis, Guillaume; Thomas, Caitlyn A; Crowder, Michael W; Dillenberger, Melissa; Becker, Katja; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Gavara, Laurent | - | |
| Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections | 1-gen-2020 | Liu, B.; Trout, R. E. L.; Chu, G. -H.; Mcgarry, D.; Jackson, R. W.; Hamrick, J. C.; Daigle, D. M.; Cusick, S. M.; Pozzi, C.; De Luca, F.; Benvenuti, M.; Mangani, S.; Docquier, J. -D.; Weiss, W. J.; Pevear, D. C.; Xerri, L.; Burns, C. J. | - | |
| VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa | 1-gen-2020 | Hamrick, J. C.; Docquier, J. -D.; Uehara, T.; Myers, C. L.; Six, D. A.; Chatwin, C. L.; John, K. J.; Vernacchio, S. F.; Cusick, S. M.; Trout, R. E. L.; Pozzi, C.; De Luca, F.; Benvenuti, M.; Mangani, S.; Liu, B.; Jackson, R. W.; Moeck, G.; Xerri, L.; Burns, C. J.; Pevear, D. C.; Daigle, D. M. | - | |
| Screen of Unfocused Libraries Identified Compounds with Direct or Synergistic Antibacterial Activity | 1-gen-2020 | Mugnaini, C.; Sannio, F.; Brizzi, A.; Del Prete, R.; Simone, T.; Ferraro, T.; De Luca, F.; Corelli, F.; Docquier, J. D. | - | |
| ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae | 1-gen-2020 | Davies, D. T.; Leiris, S.; Sprynski, N.; Castandet, J.; Lozano, C.; Bousquet, J.; Zalacain, M.; Vasa, S.; Dasari, P. K.; Pattipati, R.; Vempala, N.; Gujjewar, S.; Godi, S.; Jallala, R.; Sathyap, R. R.; Darshanoju, N. A.; Ravu, V. R.; Juventhala, R. R.; Pottabathini, N.; Sharma, S.; Pothukanuri, S.; Holden, K.; Warn, P.; Marcoccia, F.; Benvenuti, M.; Pozzi, C.; Mangani, S.; Docquier, J. D.; Lemonnier, M.; Everett, M. | - | |
| 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors | 1-gen-2020 | Gavara, L.; Sevaille, L.; De Luca, F.; Mercuri, P.; Bebrone, C.; Feller, G.; Legru, A.; Cerboni, G.; Tanfoni, S.; Baud, D.; Cutolo, G.; Bestgen, B.; Chelini, G.; Verdirosa, F.; Sannio, F.; Pozzi, C.; Benvenuti, M.; Kwapien, K.; Fischer, M.; Becker, K.; Frere, J. -M.; Mangani, S.; Gresh, N.; Berthomieu, D.; Galleni, M.; Docquier, Jd; Hernandez, J. -F. | - | |
| Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases | 1-gen-2020 | Spyrakis, F.; Santucci, M.; Maso, L.; Cross, S.; Gianquinto, E.; Sannio, F.; Verdirosa, F.; De Luca, F.; Docquier, J. D.; Cendron, L.; Tondi, D.; Venturelli, A.; Cruciani, G.; Costi, M. P. | - | |
| Isonitrile-based multicomponent synthesis of β-amino boronic acids as β-lactamase inhibitors | 1-gen-2020 | Bassini, E.; Gazzotti, S.; Sannio, F.; Presti, L. L.; Sgrignani, J.; Docquier, J. D.; Grazioso, G.; Silvani, A. | - | |
| A standard numbering scheme for class C β-lactamases | 1-gen-2020 | Mack, A. R.; Barnes, M. D.; Taracila, M. A.; Hujer, A. M.; Hujer, K. M.; Cabot, G.; Feldgarden, M.; Haft, D. H.; Klimke, W.; Van Den Akker, F.; Vila, A. J.; Smania, A.; Haider, S.; Papp-Wallace, K. M.; Bradford, P. A.; Rossolini, G. M.; Docquier, J. D.; Frere, J. -M.; Galleni, M.; Hanson, N. D.; Oliver, A.; Plesiat, P.; Poirel, L.; Nordmann, P.; Palzkill, T. G.; Jacoby, G. A.; Bush, K.; Bonomo, R. A. | - | |
| Amino acid replacement at position 228 induces fluctuation in the Ω-loop of KPC-3 and reduces the affinity against oxyimino cephalosporins: Kinetic and molecular dynamics studies | 1-gen-2020 | Piccirilli, A.; Brisdelli, F.; Docquier, J. D.; Aschi, M.; Cherubini, S.; De Luca, F.; Matagne, A.; Amicosante, G.; Perilli, M. | - | |
| 4-(N-alkyl-and-acyl-amino)-1,2,4-triazole-3-thione analogs as metallo-β-lactamase inhibitors: Impact of 4-linker on potency and spectrum of inhibition | 1-gen-2020 | Gavara, L.; Verdirosa, F.; Legru, A.; Mercuri, P. S.; Nauton, L.; Sevaille, L.; Feller, G.; Berthomieu, D.; Sannio, F.; Marcoccia, F.; Tanfoni, S.; Luca, F. D.; Gresh, N.; Galleni, M.; Docquier, J. D.; Hernandez, J. -F. | - | |
| Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii | 1-gen-2020 | Davies, D. T.; Leiris, S.; Zalacain, M.; Sprynski, N.; Castandet, J.; Bousquet, J.; Lozano, C.; Llanos, A.; Alibaud, L.; Vasa, S.; Pattipati, R.; Valige, R.; Kummari, B.; Pothukanuri, S.; De Piano, C.; Morrissey, I.; Holden, K.; Warn, P.; Marcoccia, F.; Benvenuti, M.; Pozzi, C.; Tassone, G.; Mangani, S.; Docquier, J. D.; Pallin, D.; Elliot, R.; Lemonnier, M.; Everett, M. | - | |
| SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model | 1-gen-2019 | Leiris, Simon; Coelho, Alicia; Castandet, Jérôme; Bayet, Maëlle; Lozano, Clarisse; Bougnon, Juliette; Bousquet, Justine; Everett, Martin; Lemonnier, Marc; Sprynski, Nicolas; Zalacain, Magdalena; Pallin, Thomas David; Cramp, Michael C.; Jennings, Neil; Raphy, Gilles; Jones, Mark W.; Pattipati, Ramesh; Shankar, Battu; Sivasubrahmanyam, Relangi; Soodhagani, Ashok K.; Juventhala, Ramakrishna R.; Pottabathini, Narender; Pothukanuri, Srinivasu; Benvenuti, Manuela; Pozzi, Cecilia; Mangani, Stefano; De Luca, Filomena; Cerboni, Giulia; Docquier, Jean-Denis; Davies, David T. | - | |
| Deciphering multifactorial resistance phenotypes in acinetobacter baumannii by genomics and targeted label-free proteomics | 1-gen-2018 | Cecchini, Tiphaine; Yoon, Eun-Jeong; Charretier, Yannick; Bardet, Chloé; Beaulieu, Corinne; Lacoux, Xavier; Docquier, Jean-Denis; Lemoine, Jerome; Courvalin, Patrice; Grillot-Courvalin, Catherine; Charrier, Jean-Philippe | - | |
| An update on β-lactamase inhibitor discovery and development | 1-gen-2018 | Docquier, Jean-Denis; Mangani, Stefano | - | |
| Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization | 1-gen-2018 | Pasero, Carolina; D'Agostino, Ilaria; De Luca, Filomena; Zamperini, Claudio; Deodato, Davide; Truglio, Giuseppina I.; Sannio, Filomena; DEL PRETE, Rosita; Ferraro, Teresa; Visaggio, Daniela; Mancini, Arianna; Guglielmi, Mario B.; Visca, Paolo; Docquier, Jean-Denis; Botta, Maurizio | - | |
| Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design | 1-gen-2018 | Di Pisa, Flavio; Pozzi, Cecilia; Benvenuti, Manuela; Docquier, Jean-Denis; De Luca, Filomena; Mangani, Stefano | - | |
| Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam | 1-gen-2018 | Pozzi, Cecilia; Di Pisa, Flavio; De Luca, Filomena; Benvenuti, Manuela; Docquier, Jean Denis; Mangani, Stefano | - |
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