Sfoglia per Autore
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties
2023-01-01 Grazia Martina, Maria; Giammarino, Federica; Vicenti, Ilaria; Groaz, Elisabetta; Rozenski, Jef; Incerti, Matteo; Sannio, Filomena; Docquier, Jean Denis; Zazzi, Maurizio; Radi, Marco
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect
2022-01-01 Martina, Maria Grazia; Sannio, Filomena; Crespan, Emmanuele; Pavone, Marialaura; Simoncini, Alice; Barbieri, Francesca; Perini, Cecilia; Pesce, Emanuela; Maga, Giovanni; Pedemonte, Nicoletta; Docquier, Jean-Denis; Radi, Marco
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2
2021-01-01 Vicenti, Ilaria; Martina, Maria Grazia; Boccuto, Adele; De Angelis, Marta; Giavarini, Giorgia; Dragoni, Filippo; Marchi, Serena; Trombetta, Claudia Maria; Crespan, Emmanuele; Maga, Giovanni; Eydoux, Cecilia; Decroly, Etienne; Montomoli, Emanuele; Nencioni, Lucia; Zazzi, Maurizio; Radi, Marco
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma
2015-01-01 Tintori, Cristina; Fallacara, A. L.; Radi, Marco; Zamperini, Claudio; Dreassi, Elena; Crespan, E.; Maga, G.; Schenone, S.; Musumeci, F.; Brullo, C.; Richters, A.; Gasparrini, F.; Angelucci, A.; Festuccia, C.; Delle Monache, S.; Rauh, D.; Botta, M.
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors
2015-01-01 Tintori, Cristina; La Sala, Giuseppina; Vignaroli, Giulia; Botta, Lorenzo; Fallacara, Anna Lucia; Falchi, Federico; Radi, Marco; Zamperini, Claudio; Dreassi, Elena; Dello Iacono, Lucia; Orioli, Donata; Biamonti, Giuseppe; Garbelli, Mirko; Lossani, Andrea; Gasparrini, Francesca; Tuccinardi, Tiziano; Laurenzana, Ilaria; Angelucci, Adriano; Maga, Giovanni; Schenone, Silvia; Brullo, Chiara; Musumeci, Francesca; Desogus, Andrea; Crespan, Emmanuele; Botta, Maurizio
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction
2014-01-01 Zamperini, C.; Dreassi, E.; Vignaroli, G.; Radi, M.; Dragoni, S.; Schenone, S.; Musumeci, F.; Valoti, M.; Antiochia, R.; Botta, M.
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors
2013-01-01 Vignaroli, Giulia; Zamperini, Claudio; Dreassi, Elena; Radi, Marco; Angelucci, A.; Sanità, P.; Crespan, E.; Kissova, M.; Maga, G.; Schenone, S.; Musumeci, F.; Botta, Maurizio
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulation
2012-01-01 Radi, M.; Evensen, L.; Dreassi, E.; Zamperini, C.; Caporicci, M.; Falchi, F.; Musumeci, A.; Schenone, S.; Lorens, J. B.; Botta, M.
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study
2011-01-01 Radi, Marco; Dreassi, Elena; C., Brullo; E., Crespan; Tintori, Cristina; V., Bernardo; Valoti, Massimo; Zamperini, Claudio; H., Daigl; F., Musumeci; Carraro, Fabio; Naldini, Antonella; Filippi, Irene; G., Maga; S., Schenone; Botta, Maurizio
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication
2011-01-01 Garbelli, A.; Radi, M.; Falchi, F.; Beermann, S.; Zanoli, S.; Manetti, F.; Dietrich, U.; Botta, M.; Maga, G.
HIV-1 RT inhibitors with a novel mechanism of action: NNRTIs that compete with the nucleotide substrate
2010-01-01 Maga, G.; Radi, Marco; Gerard, M.; Botta, Maurizio; Ennifar, E.
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action
2010-01-01 Freisz, S.; Bec, G.; Radi, Marco; Wolff, P.; Crespan, E.; Angeli, Lucilla; Dumas, P.; Maga, G.; Botta, Maurizio; Ennifar, E.
New insights into small-molecule inhibitors of Bcr-Abl
2010-01-01 Schenone, S.; Botta, Maurizio; Radi, Marco; Bruno, O.
A Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives
2010-01-01 Radi, Marco; Botta, Lorenzo; Casaluce, Gianni; Bernardini, Martina; Botta, Maurizio
Arylation of 2-Furyl 4-Fluorophenyl Ketone: an extension of Heck Chemistry towards Novel Integrase Inhibitors
2010-01-01 Franchi, Luigi; Rinaldi, Marta; Vignaroli, Giulia; Innitzer, Anna; Radi, Marco; Botta, Maurizio
4-Aminosubstituted pyrazolo[3,4d]pyrimidines: synthesis and biological properties
2009-01-01 Schenone, S.; Bruno, O.; Radi, Marco; Botta, Maurizio
Recent highlights in the synthesis of highly functionalized pyrimidines
2009-01-01 Radi, Marco; Botta, Maurizio; Schenone, S.
Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles
2009-01-01 Radi, Marco; Bernardo, Vincenzo; Bechi, Beatrice; Castagnolo, Daniele; Pagano, Mafalda; Botta, Maurizio
NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-D PYRIMIDINE AND PYRROLO[2,3-D]PYRIMIDINE AND USES THEREOF | [NOUVEAUX DÉRIVÉS 4-SUBSTITUÉS DE LA PYRAZOLO[3,4-D]PYRIMIDINE ET DE LA PYRROLO[2,3-D]PYRIMIDINE ET LEURS UTILISATIONS]
2009-01-01 Schenone, Silvia; Bondavalli, Francesco; Bruno, Olga; Botta, Maurizio; Manetti, Fabrizio; Radi, Marco; Santucci, Alessandra; Maga, Giovanni; Bologna, Mauro; Angelucci, Adriano; Santucci, Annalisa; Spreafico, Adriano; Carraro, Fabio; Borlak, Jurgen
A Multidisciplinary Approach for the Identification ofNovel HIV-1 Non-Nucleoside Reverse TranscriptaseInhibitors: S-DABOCs and DAVPs
2008-01-01 Radi, Marco; Falciani, Chiara; Contemori, Lorenzo; Petricci, Elena; Maga, G.; Samuele, A.; Zanoli, S.; Terrazas, M.; Castria, Marinunzia; Togninelli, Andrea; Esté, J. A.; Clotet Codina, I.; Armand Ugon, M.; Botta, Maurizio
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties | 1-gen-2023 | Grazia Martina, Maria; Giammarino, Federica; Vicenti, Ilaria; Groaz, Elisabetta; Rozenski, Jef; Incerti, Matteo; Sannio, Filomena; Docquier, Jean Denis; Zazzi, Maurizio; Radi, Marco | - | |
| Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect | 1-gen-2022 | Martina, Maria Grazia; Sannio, Filomena; Crespan, Emmanuele; Pavone, Marialaura; Simoncini, Alice; Barbieri, Francesca; Perini, Cecilia; Pesce, Emanuela; Maga, Giovanni; Pedemonte, Nicoletta; Docquier, Jean-Denis; Radi, Marco | - | |
| System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2 | 1-gen-2021 | Vicenti, Ilaria; Martina, Maria Grazia; Boccuto, Adele; De Angelis, Marta; Giavarini, Giorgia; Dragoni, Filippo; Marchi, Serena; Trombetta, Claudia Maria; Crespan, Emmanuele; Maga, Giovanni; Eydoux, Cecilia; Decroly, Etienne; Montomoli, Emanuele; Nencioni, Lucia; Zazzi, Maurizio; Radi, Marco | - | |
| Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma | 1-gen-2015 | Tintori, Cristina; Fallacara, A. L.; Radi, Marco; Zamperini, Claudio; Dreassi, Elena; Crespan, E.; Maga, G.; Schenone, S.; Musumeci, F.; Brullo, C.; Richters, A.; Gasparrini, F.; Angelucci, A.; Festuccia, C.; Delle Monache, S.; Rauh, D.; Botta, M. | - | |
| Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors | 1-gen-2015 | Tintori, Cristina; La Sala, Giuseppina; Vignaroli, Giulia; Botta, Lorenzo; Fallacara, Anna Lucia; Falchi, Federico; Radi, Marco; Zamperini, Claudio; Dreassi, Elena; Dello Iacono, Lucia; Orioli, Donata; Biamonti, Giuseppe; Garbelli, Mirko; Lossani, Andrea; Gasparrini, Francesca; Tuccinardi, Tiziano; Laurenzana, Ilaria; Angelucci, Adriano; Maga, Giovanni; Schenone, Silvia; Brullo, Chiara; Musumeci, Francesca; Desogus, Andrea; Crespan, Emmanuele; Botta, Maurizio | - | |
| CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction | 1-gen-2014 | Zamperini, C.; Dreassi, E.; Vignaroli, G.; Radi, M.; Dragoni, S.; Schenone, S.; Musumeci, F.; Valoti, M.; Antiochia, R.; Botta, M. | - | |
| Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors | 1-gen-2013 | Vignaroli, Giulia; Zamperini, Claudio; Dreassi, Elena; Radi, Marco; Angelucci, A.; Sanità, P.; Crespan, E.; Kissova, M.; Maga, G.; Schenone, S.; Musumeci, F.; Botta, Maurizio | - | |
| A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulation | 1-gen-2012 | Radi, M.; Evensen, L.; Dreassi, E.; Zamperini, C.; Caporicci, M.; Falchi, F.; Musumeci, A.; Schenone, S.; Lorens, J. B.; Botta, M. | - | |
| Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study | 1-gen-2011 | Radi, Marco; Dreassi, Elena; C., Brullo; E., Crespan; Tintori, Cristina; V., Bernardo; Valoti, Massimo; Zamperini, Claudio; H., Daigl; F., Musumeci; Carraro, Fabio; Naldini, Antonella; Filippi, Irene; G., Maga; S., Schenone; Botta, Maurizio | - | |
| Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication | 1-gen-2011 | Garbelli, A.; Radi, M.; Falchi, F.; Beermann, S.; Zanoli, S.; Manetti, F.; Dietrich, U.; Botta, M.; Maga, G. | - | |
| HIV-1 RT inhibitors with a novel mechanism of action: NNRTIs that compete with the nucleotide substrate | 1-gen-2010 | Maga, G.; Radi, Marco; Gerard, M.; Botta, Maurizio; Ennifar, E. | - | |
| Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action | 1-gen-2010 | Freisz, S.; Bec, G.; Radi, Marco; Wolff, P.; Crespan, E.; Angeli, Lucilla; Dumas, P.; Maga, G.; Botta, Maurizio; Ennifar, E. | - | |
| New insights into small-molecule inhibitors of Bcr-Abl | 1-gen-2010 | Schenone, S.; Botta, Maurizio; Radi, Marco; Bruno, O. | - | |
| A Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives | 1-gen-2010 | Radi, Marco; Botta, Lorenzo; Casaluce, Gianni; Bernardini, Martina; Botta, Maurizio | - | |
| Arylation of 2-Furyl 4-Fluorophenyl Ketone: an extension of Heck Chemistry towards Novel Integrase Inhibitors | 1-gen-2010 | Franchi, Luigi; Rinaldi, Marta; Vignaroli, Giulia; Innitzer, Anna; Radi, Marco; Botta, Maurizio | - | |
| 4-Aminosubstituted pyrazolo[3,4d]pyrimidines: synthesis and biological properties | 1-gen-2009 | Schenone, S.; Bruno, O.; Radi, Marco; Botta, Maurizio | - | |
| Recent highlights in the synthesis of highly functionalized pyrimidines | 1-gen-2009 | Radi, Marco; Botta, Maurizio; Schenone, S. | - | |
| Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles | 1-gen-2009 | Radi, Marco; Bernardo, Vincenzo; Bechi, Beatrice; Castagnolo, Daniele; Pagano, Mafalda; Botta, Maurizio | - | |
| NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-D PYRIMIDINE AND PYRROLO[2,3-D]PYRIMIDINE AND USES THEREOF | [NOUVEAUX DÉRIVÉS 4-SUBSTITUÉS DE LA PYRAZOLO[3,4-D]PYRIMIDINE ET DE LA PYRROLO[2,3-D]PYRIMIDINE ET LEURS UTILISATIONS] | 1-gen-2009 | Schenone, Silvia; Bondavalli, Francesco; Bruno, Olga; Botta, Maurizio; Manetti, Fabrizio; Radi, Marco; Santucci, Alessandra; Maga, Giovanni; Bologna, Mauro; Angelucci, Adriano; Santucci, Annalisa; Spreafico, Adriano; Carraro, Fabio; Borlak, Jurgen | - | |
| A Multidisciplinary Approach for the Identification ofNovel HIV-1 Non-Nucleoside Reverse TranscriptaseInhibitors: S-DABOCs and DAVPs | 1-gen-2008 | Radi, Marco; Falciani, Chiara; Contemori, Lorenzo; Petricci, Elena; Maga, G.; Samuele, A.; Zanoli, S.; Terrazas, M.; Castria, Marinunzia; Togninelli, Andrea; Esté, J. A.; Clotet Codina, I.; Armand Ugon, M.; Botta, Maurizio | - |
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