A number of immune related pathologies, such as autoimmune and allergic disorders, develop as the result of an imbalance among Th subsets. A Th1 bias has been consistently observed in autoimmunity both in man and in mouse, which has led to the notion that autoimmunity is a disease initiated by an abnormal polarization of CD4+ T cells towards the proinflammatory Th1 lineage. In addition to Th1 and Th2 cells, a third subset of effector Th cells producing IL-17 has recently been described and termed Th17. Th17 cells have been causally associated to the pathogenesis of human autoimmune diseases, of which multiple sclerosis is a striking example. Recent data have identified molecular adaptors as master regulators not only of T-cell activation, but also of Th cell development, highlighting these molecules as attractive targets for pharmacological manipulation. We have recently demonstrated that loss of Rai, a member of the Shc family expressed both in neuronal and in T cells, results in the development of systemic autoimmunity (Savino et al 2009). Since peripheral T cells from Rai -/- mice show an up-regulation of the Th17 cytokines we addressed the potential role of Rai in the signaling pathways controlling Th17 development and in the pathogenesis of multiple sclerosis. Our results indicate that Rai interferes with Th17 development by altering key steps of the signaling pathways triggered by TCR in combination with TGFβ and IL-6 and alter the severity of EAE disease.

Savino, M.T., Ulivieri, C., Aldinucci, A., DE FALCO, G., Ballerini, C., Pelicci, M.M., et al. (2011). Altered balance of helper T cells in Rai-/- mice. In EMBO Conference series Signaling in the immune system.

Altered balance of helper T cells in Rai-/- mice

SAVINO, MARIA TERESA;ULIVIERI, CRISTINA;DE FALCO, GIULIA;BALDARI, COSIMA
2011-01-01

Abstract

A number of immune related pathologies, such as autoimmune and allergic disorders, develop as the result of an imbalance among Th subsets. A Th1 bias has been consistently observed in autoimmunity both in man and in mouse, which has led to the notion that autoimmunity is a disease initiated by an abnormal polarization of CD4+ T cells towards the proinflammatory Th1 lineage. In addition to Th1 and Th2 cells, a third subset of effector Th cells producing IL-17 has recently been described and termed Th17. Th17 cells have been causally associated to the pathogenesis of human autoimmune diseases, of which multiple sclerosis is a striking example. Recent data have identified molecular adaptors as master regulators not only of T-cell activation, but also of Th cell development, highlighting these molecules as attractive targets for pharmacological manipulation. We have recently demonstrated that loss of Rai, a member of the Shc family expressed both in neuronal and in T cells, results in the development of systemic autoimmunity (Savino et al 2009). Since peripheral T cells from Rai -/- mice show an up-regulation of the Th17 cytokines we addressed the potential role of Rai in the signaling pathways controlling Th17 development and in the pathogenesis of multiple sclerosis. Our results indicate that Rai interferes with Th17 development by altering key steps of the signaling pathways triggered by TCR in combination with TGFβ and IL-6 and alter the severity of EAE disease.
Savino, M.T., Ulivieri, C., Aldinucci, A., DE FALCO, G., Ballerini, C., Pelicci, M.M., et al. (2011). Altered balance of helper T cells in Rai-/- mice. In EMBO Conference series Signaling in the immune system.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/975608