Purpose: The acquisition time in CT perfusion studies significantly affects patient’s dose exposure. In order to reduce the radiation dose, reduced time CT perfusion acquisitions are tested to measure PS with a deconvolution method. Methods and Materials: PS was calculated with repeated measurements (n=259) while truncating the time density curve at different time values in 11 CT perfusion studies conducted for lung cancer (n=2), Hodgkin lymphoma (n=7) and renal cell carcinoma (n=2), using CT perfusion 4D software (GE Healthcare). The median acquisition time of CT perfusion studies was 62 sec (range 49-120 sec). To verify the accuracy of the deconvolution algorithm, a variation of the truncated PS within the error measurements was searched, i.e. within 3 standard deviations from the mean nominal error provided by the software. As a sanity check the test was performed for all the parameters measured using CT Perfusion 4D software. Results: PS was consistent within 7% in ~10 to ~20 seconds; and within 0.9% in ~20 to ~23 seconds; PS was constant after 25 to 35 sec. A consistent result lasted for all the observed parameters (MTT, BV, BF) as expected from their analytical dependence. Conclusion: Thirty-five seconds are enough to obtain a reliable IRF (impulse residual function). For an accurate measurement of the PS a 45 sec acquisition time should be an optimal compromise to obtain reliable PS measurements and a reasonable dose exposure. No additional information can be provided with longer perfusion acquisition times.

Mazzei, M.A., E., S., Guerrini, S., CIOFFI SQUITIERI, N., E., F., C., d.M., et al. (2012). Reduced time CT perfusion acquisitions are sufficient to measure the permeability surface area product with a deconvolution method. In Insights into Imaging (pp.166-166).

Reduced time CT perfusion acquisitions are sufficient to measure the permeability surface area product with a deconvolution method

MAZZEI, MARIA ANTONIETTA;GUERRINI, SUSANNA;CIOFFI SQUITIERI, NEVADA;MAZZEI, FRANCESCO;VOLTERRANI, LUCA
2012

Abstract

Purpose: The acquisition time in CT perfusion studies significantly affects patient’s dose exposure. In order to reduce the radiation dose, reduced time CT perfusion acquisitions are tested to measure PS with a deconvolution method. Methods and Materials: PS was calculated with repeated measurements (n=259) while truncating the time density curve at different time values in 11 CT perfusion studies conducted for lung cancer (n=2), Hodgkin lymphoma (n=7) and renal cell carcinoma (n=2), using CT perfusion 4D software (GE Healthcare). The median acquisition time of CT perfusion studies was 62 sec (range 49-120 sec). To verify the accuracy of the deconvolution algorithm, a variation of the truncated PS within the error measurements was searched, i.e. within 3 standard deviations from the mean nominal error provided by the software. As a sanity check the test was performed for all the parameters measured using CT Perfusion 4D software. Results: PS was consistent within 7% in ~10 to ~20 seconds; and within 0.9% in ~20 to ~23 seconds; PS was constant after 25 to 35 sec. A consistent result lasted for all the observed parameters (MTT, BV, BF) as expected from their analytical dependence. Conclusion: Thirty-five seconds are enough to obtain a reliable IRF (impulse residual function). For an accurate measurement of the PS a 45 sec acquisition time should be an optimal compromise to obtain reliable PS measurements and a reasonable dose exposure. No additional information can be provided with longer perfusion acquisition times.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/44701
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