Background Health Related Quality of Life (HRQL) have been demonstrated to be influenced by the coexistence of multiple chronic diseases.Additional studies are needed to clarify this association especially because few researches investigated the influence of severity of disease. Aim To investigate the influence of comorbidities and severity of disease on HRQL. Methods In 2009/10 the questionnaire SF36- 8 scales scored 0-100:physical functioning(PF),physical role(PR),pain(PN),general health(GH),vitality (VT),social functions(SF),emotional role (ER),mental health (MH)- was distributed to 887 patients of general practitioners (GP) in Siena’s province, Tuscany-Italy.Information from GP were gathered to calculate Charlson Index (CI) and Cumulative Illness Rating Scale (CIRS) for each patient.CI produces a comorbidity index summing diseases’ associated weights and adding one point for each decade after 40 years.CIRS produces a severity score as the mean weight of severity(5 levels) of coexisting illnesses.Information about gender, age, marital status, employment, BMI, smoking were collected.We used Spearman's rho to study the correlation between SF36 scales, CI and CIRS scores.Association between SF36 scales, CI a CIRS was studied using multivariate nonparametric quantile regression adjusting for above confounders. Results Females were 63.7%, mean age 58.7.SF36 higher mean score was in PF scale (82.3 SD=23.3), lower in VT (59 SD=19,6). CI and CIRS mean scores were 3.5 SD=3 and 0.23 SD=0.25.CI and CIRS were inversely correlate mainly with physical scales of SF36 (respectively, PF rho=-0.5 and rho=-0.4); CI and CIRS were highly correlated (rho=0.8). After multivariate analysis CI resulted associated with CIRS (coeff.=5.7, p<0.001), PF scale (-1.7, p<0.001), PR (-1.7, p=0.013), GH (-1.4, p=0.039); CIRS was associated with PF scale (- 13.3, p<0.001), PR (-33.9, p<0.001), PN (-35.5, p<0.001), GH (-16.3, p=0.011), VT (-10.5, p=0.006), MH (-14.9, p=0.004). Conclusions In an adult population of primary care patients, comorbidity and severity of disease adversely influenced HRQL.Comorbidity seems to influence scales which describe physical characteristic of HRQL, severity is also associated to emotional/mental aspects.Comorbidity and severity resulted highly correlated.

Quercioli, C., Nistico', F., Barducci, M., Messina, G., Carriero, G., Moirano, F., et al. (2012). I feel like I'm? A comparison of objective and subjective measures of health in general practitioners' patients. EUROPEAN JOURNAL OF PUBLIC HEALTH, 22 Supplement 2, 134-134.

I feel like I'm? A comparison of objective and subjective measures of health in general practitioners' patients

MESSINA, GABRIELE;NANTE, NICOLA
2012-01-01

Abstract

Background Health Related Quality of Life (HRQL) have been demonstrated to be influenced by the coexistence of multiple chronic diseases.Additional studies are needed to clarify this association especially because few researches investigated the influence of severity of disease. Aim To investigate the influence of comorbidities and severity of disease on HRQL. Methods In 2009/10 the questionnaire SF36- 8 scales scored 0-100:physical functioning(PF),physical role(PR),pain(PN),general health(GH),vitality (VT),social functions(SF),emotional role (ER),mental health (MH)- was distributed to 887 patients of general practitioners (GP) in Siena’s province, Tuscany-Italy.Information from GP were gathered to calculate Charlson Index (CI) and Cumulative Illness Rating Scale (CIRS) for each patient.CI produces a comorbidity index summing diseases’ associated weights and adding one point for each decade after 40 years.CIRS produces a severity score as the mean weight of severity(5 levels) of coexisting illnesses.Information about gender, age, marital status, employment, BMI, smoking were collected.We used Spearman's rho to study the correlation between SF36 scales, CI and CIRS scores.Association between SF36 scales, CI a CIRS was studied using multivariate nonparametric quantile regression adjusting for above confounders. Results Females were 63.7%, mean age 58.7.SF36 higher mean score was in PF scale (82.3 SD=23.3), lower in VT (59 SD=19,6). CI and CIRS mean scores were 3.5 SD=3 and 0.23 SD=0.25.CI and CIRS were inversely correlate mainly with physical scales of SF36 (respectively, PF rho=-0.5 and rho=-0.4); CI and CIRS were highly correlated (rho=0.8). After multivariate analysis CI resulted associated with CIRS (coeff.=5.7, p<0.001), PF scale (-1.7, p<0.001), PR (-1.7, p=0.013), GH (-1.4, p=0.039); CIRS was associated with PF scale (- 13.3, p<0.001), PR (-33.9, p<0.001), PN (-35.5, p<0.001), GH (-16.3, p=0.011), VT (-10.5, p=0.006), MH (-14.9, p=0.004). Conclusions In an adult population of primary care patients, comorbidity and severity of disease adversely influenced HRQL.Comorbidity seems to influence scales which describe physical characteristic of HRQL, severity is also associated to emotional/mental aspects.Comorbidity and severity resulted highly correlated.
2012
Quercioli, C., Nistico', F., Barducci, M., Messina, G., Carriero, G., Moirano, F., et al. (2012). I feel like I'm? A comparison of objective and subjective measures of health in general practitioners' patients. EUROPEAN JOURNAL OF PUBLIC HEALTH, 22 Supplement 2, 134-134.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/43907
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