Juvenile granulosa cell tumor in 11-day-old neonate

Background: Neonatal testicular tumors are rare and they should be considered in thè differential diagnosis of a newborn scrotal mass. We present a case report of a newborn with rare type of testis tumor: Juvenile granulose celi tumor. Case report: We present a newborn admitted to our department for evaluation of "left scrotal mass" on thè 11 days after thè birth. Fetal ultrasound at 36 gestational weeks showed alteration of left testis that it was confirmed at thè birth. We performed abdominal and testis ultrasound, karyotype, blood exams and hormonal evaluation. Abdominal ultrasound was normal. Testis scans confirmed thè presence of cystic lesion in thè left gonad. Blood exams were normal. Serum tumors markers were drawn with thè following results: alphafetoprotein (AFP) was 6679 Ul/ml, Human chorionic gonadotropin 8 mUI/ml, testosterone 1.75ng/ml, inibina B 346 pg/ml. Karyotyping showed normal 46 XY chromosomes as chorionic villus sampling has showed during pregnancy. According to parents, thè patient underwent an uncomplicated left radicai orchidectomy and thè histological diagnosis was Juvenile granulosa celi tumor. Today thè patient is healty. Conclusions: Juvenile granulose cell tumor represents about 5% of all prepuberal testis tumors. It is a benign neoplasm, hormonally inactive and its prognosis is very good. It is usually diagnosed in thè first year of life. The its typical clinical presentation is a painless testicular mass. The radicai orchiectomy is sufficient for treatment. Although neonatal testicular tumors are rare, they should be considered in thè difFerential diagnosis of a newborn scrotal mass. Also, each testicular mass should be considered pathologic until proven otherwise. In suspected of a testicular neoplastic disease, in fact, early diagnosis and treatment are correlated with optimal prognosis.