Introduction: Dukes’ B cancer represents a wide spectrum of disease from early penetration through the bowel wall to aggres-sive and extensive tumors with extramural venous spread and involvement of the serosa, surgical margins, or adjacent organs. Among Dukes’ B cancers, Petersen index (PI) allow a stratification in order to identify those patients for whom chemotherapy may be of benefit. Population under Study: 210 resected patients with CRC Dukes’ B were included prospectively in a database and considered in the present study. According to PI, a score (from 0 to 4) for each patients was calculated on the basis of peritoneal and margin involvement, venous invasion and tumor perforation. Results: 49 out of 210 tumors were located in the Rectum and 161 in the Colon. According to PI score 169 patients had a score of 0, 26 of 1 and 15 of ≥2. The overall R0 resection was achieved in 94.2% of cases and the majority of patients with PI score of ≥2 were R1-2. The mean of harvested lymph nodes was 16.9 with no difference according to the PI score. Patients with PI score of 0 had a 5-year survival rate of 92.3%, significantly higher if compared with those with PI score 1 (71.4%) and ≥2 (46.7%). Conclusion: Even though in our experience the influence of PI score on survival is confirmed, we underline that a comparison with additional clinical and histological prognostic factors should be needed
G., C., Marrelli, D., F., B., S., C., C., P., Neri, A., et al. (2009). Petersen Index Score in Dukes’ B Colorectal Cancer. Our Experience on 210 Consecutive Patients. EUROPEAN SURGICAL RESEARCH, 43, 164-164.
Petersen Index Score in Dukes’ B Colorectal Cancer. Our Experience on 210 Consecutive Patients
MARRELLI, DANIELE;NERI, ALESSANDRO;PINTO, ENRICO;ROVIELLO, FRANCO
2009-01-01
Abstract
Introduction: Dukes’ B cancer represents a wide spectrum of disease from early penetration through the bowel wall to aggres-sive and extensive tumors with extramural venous spread and involvement of the serosa, surgical margins, or adjacent organs. Among Dukes’ B cancers, Petersen index (PI) allow a stratification in order to identify those patients for whom chemotherapy may be of benefit. Population under Study: 210 resected patients with CRC Dukes’ B were included prospectively in a database and considered in the present study. According to PI, a score (from 0 to 4) for each patients was calculated on the basis of peritoneal and margin involvement, venous invasion and tumor perforation. Results: 49 out of 210 tumors were located in the Rectum and 161 in the Colon. According to PI score 169 patients had a score of 0, 26 of 1 and 15 of ≥2. The overall R0 resection was achieved in 94.2% of cases and the majority of patients with PI score of ≥2 were R1-2. The mean of harvested lymph nodes was 16.9 with no difference according to the PI score. Patients with PI score of 0 had a 5-year survival rate of 92.3%, significantly higher if compared with those with PI score 1 (71.4%) and ≥2 (46.7%). Conclusion: Even though in our experience the influence of PI score on survival is confirmed, we underline that a comparison with additional clinical and histological prognostic factors should be neededFile | Dimensione | Formato | |
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https://hdl.handle.net/11365/31924
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