Pyridazinone antagonists of α1-adrenergic receptors were prepd. that have the general formulas (I), where X = OMe, OEt, or OCHMe2, n = 2-7, Y = Cl or Br, and R = (2-furoyl)piperazin-1-yl, [2-(1,4-benzodioxan)methyl]piperazin-1-yl, or 4-[2-(ethoxyphenoxy)ethyl]piperazin-1-yl; or I with Y and R reversed; or (II), where X = OMe or OEt or Cl, n = 2-7, R = derivs. of indole, benzimidazole, or imidazole according to the values assigned to X and n. Data are presented on the α1-adrenergic receptor-binding activities of thes compds., which are intended to be used in treatment of benign prostatic hypertrophy or hypertension. Methods of synthesizing these compds. are disclosed also.

Betti, L., Botta, M., Floridi, M., Giannaccini, G., Manetti, F., Strappaghetti, G. (2004)Preparing pyridazinone derivatives for use as α1-adrenergic receptor antagonists. . Brevetto No. IT 2002RM0362.

Preparing pyridazinone derivatives for use as α1-adrenergic receptor antagonists

BOTTA, MAURIZIO;MANETTI, FABRIZIO;
2004-01-01

Abstract

Pyridazinone antagonists of α1-adrenergic receptors were prepd. that have the general formulas (I), where X = OMe, OEt, or OCHMe2, n = 2-7, Y = Cl or Br, and R = (2-furoyl)piperazin-1-yl, [2-(1,4-benzodioxan)methyl]piperazin-1-yl, or 4-[2-(ethoxyphenoxy)ethyl]piperazin-1-yl; or I with Y and R reversed; or (II), where X = OMe or OEt or Cl, n = 2-7, R = derivs. of indole, benzimidazole, or imidazole according to the values assigned to X and n. Data are presented on the α1-adrenergic receptor-binding activities of thes compds., which are intended to be used in treatment of benign prostatic hypertrophy or hypertension. Methods of synthesizing these compds. are disclosed also.
2004
Betti, L., Botta, M., Floridi, M., Giannaccini, G., Manetti, F., Strappaghetti, G. (2004)Preparing pyridazinone derivatives for use as α1-adrenergic receptor antagonists. . Brevetto No. IT 2002RM0362.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/29902
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo