Pyridazinone antagonists of α1-adrenergic receptors were prepd. that have the general formulas (I), where X = OMe, OEt, or OCHMe2, n = 2-7, Y = Cl or Br, and R = (2-furoyl)piperazin-1-yl, [2-(1,4-benzodioxan)methyl]piperazin-1-yl, or 4-[2-(ethoxyphenoxy)ethyl]piperazin-1-yl; or I with Y and R reversed; or (II), where X = OMe or OEt or Cl, n = 2-7, R = derivs. of indole, benzimidazole, or imidazole according to the values assigned to X and n. Data are presented on the α1-adrenergic receptor-binding activities of thes compds., which are intended to be used in treatment of benign prostatic hypertrophy or hypertension. Methods of synthesizing these compds. are disclosed also.
Betti, L., Botta, M., Floridi, M., Giannaccini, G., Manetti, F., Strappaghetti, G. (2004)Preparing pyridazinone derivatives for use as α1-adrenergic receptor antagonists. . Brevetto No. IT 2002RM0362.
Preparing pyridazinone derivatives for use as α1-adrenergic receptor antagonists
BOTTA, MAURIZIO;MANETTI, FABRIZIO;
2004-01-01
Abstract
Pyridazinone antagonists of α1-adrenergic receptors were prepd. that have the general formulas (I), where X = OMe, OEt, or OCHMe2, n = 2-7, Y = Cl or Br, and R = (2-furoyl)piperazin-1-yl, [2-(1,4-benzodioxan)methyl]piperazin-1-yl, or 4-[2-(ethoxyphenoxy)ethyl]piperazin-1-yl; or I with Y and R reversed; or (II), where X = OMe or OEt or Cl, n = 2-7, R = derivs. of indole, benzimidazole, or imidazole according to the values assigned to X and n. Data are presented on the α1-adrenergic receptor-binding activities of thes compds., which are intended to be used in treatment of benign prostatic hypertrophy or hypertension. Methods of synthesizing these compds. are disclosed also.
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https://hdl.handle.net/11365/29902
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