Title compds. [I; X = CH, N; R = H, alkylthio, alkylamino, cycloalkyl, cycloalkylthio, cycloalkylamino, alkyl, etc.; R1 = NHR6, N(R6)2; R6 = alkyl, cycloalkyl, pyrrolidinyl, morpholino, hexahydroazepinyl, (substituted) (hetero)aryl(alkyl)], were prepd. Thus, title compd. (II) (multistep prepn. outlined) after 48 h reduced cellular viability of SaOS-2 cells to 15.1% of controls.

Chenone, S., Bondavalli, F., Bruno, O., Botta, M., Manetti, F., Radi, M., et al. (2009)Preparation of pyrazolo[3,4-d]pyrimidines and pyrrolo[2,3-d]pyrimidines for treatment of bone related diseases and tumors.. . Brevetto No. WO 2009034547.

Preparation of pyrazolo[3,4-d]pyrimidines and pyrrolo[2,3-d]pyrimidines for treatment of bone related diseases and tumors.

BOTTA, MAURIZIO;MANETTI, FABRIZIO;SANTUCCI, ANNALISA;Carraro, Fabio;
2009-01-01

Abstract

Title compds. [I; X = CH, N; R = H, alkylthio, alkylamino, cycloalkyl, cycloalkylthio, cycloalkylamino, alkyl, etc.; R1 = NHR6, N(R6)2; R6 = alkyl, cycloalkyl, pyrrolidinyl, morpholino, hexahydroazepinyl, (substituted) (hetero)aryl(alkyl)], were prepd. Thus, title compd. (II) (multistep prepn. outlined) after 48 h reduced cellular viability of SaOS-2 cells to 15.1% of controls.
2009
Chenone, S., Bondavalli, F., Bruno, O., Botta, M., Manetti, F., Radi, M., et al. (2009)Preparation of pyrazolo[3,4-d]pyrimidines and pyrrolo[2,3-d]pyrimidines for treatment of bone related diseases and tumors.. . Brevetto No. WO 2009034547.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/27628
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo