Development of sustainable processes for API production

The emergence of the green chemistry revolution poses new challenges for the chemical industry, education and research. These challenges include exploring alternative reaction conditions to increase selectivity and reduce energy consumption. In addition, the development of chemical compounds with lower hazards and safer characteristics presents further complexities. However, these challenges are opportunities for innovation and introduction of new chemical processes that can improve the economic sustainability of chemical production and change the perception of chemistry itself. In this thesis, I present promising advances towards sustainable chemical synthesis that have significant implications for industrial applications. A new and safer method for the synthesis of pyrazole derivatives was developed by exploring the production of diazo compounds in an aqueous micellar environment. The one-pot process involves the reaction of glycine derivatives with NaNO2 in the presence of a dipolarophile, enabling the in situ cycloaddition of diazo derivatives with alkynes and eliminating the need to isolate hazardous diazo intermediates. A feasibility study for an alternative industrial, environmentally friendly synthesis of fezolinetant, a selective NK3 receptor antagonist, is described. The synthetic strategies focus on minimizing waste, selecting less toxic reagents and solvents, and maintaining precise stoichiometry. A mild C-H coupling reaction was developed on a multigram scale to synthesize a triazolopyrazine-thiadiazole intermediate. Potential syntheses of diastereomers for the amino alcohol intermediate of rimegepant, an oral CGRP antagonist for the treatment of migraine, were explored. This investigation provided the necessary support for the analytical development and evaluation of the enantio- and diastereomeric purity of the final product during the industrial development of rimegepant. A fourth section is dedicated to the design and development of a fluorinated derivative of L-carnitine.