Ruthenium nanomicellar catalysis under MW irradiation” and “Development of an alternative synthetic strategy for Sepiapterin"

The first project regards the academic research and have the aim to develop new sustainable synthesis through nanomicellar catalytic system assisted with MW irradiation. The second project is based on the investigation for alternative synthesis of Sepiapterin, an orphan drug used for the treatment of PKU, without infringing its Patent. The first part of my thesis, as already mentioned before, will describe the development of a new synthetical method for the synthesis of organic compounds combining two technologies already known in green chemistry: Microwave dielectric heating and nanomicellar catalyst. The second chapter of this thesis was done during my internship in Dipharma Francis laboratories and will look to the development of a new synthetic route for the orphan drug Sepiapterin), a precursor of the cofactor tetrahydrobiopterin for the enzyme DHPR (dihydropterin reductase) for the treatment of a rare metabolic disorder known as Phenylketonuria (PKU.