The cerebellum adapts motor responses by controlling the gain of a movement, preserving its accuracy and by learning from endpoint errors. Adaptive behavior likely acts not only in the motor but also in the sensory, behavioral, and cognitive domains, thus supporting a role of cerebellum in monitoring complex brain performances. Here, we analyzed the relationship between saccade latency, duration and endpoint error of antisaccades in a group of 10 idiopathic cerebellar atrophy (ICA) patients compared to controls. The latency distribution was decomposed in a decision time and a residual time. Both groups showed a trade-off between duration and decision time, with a peak of entropy within the range of this trade-off where the information flow was maximized. In cerebellar patients, greater reductions of duration as the time of decision increased, were associated with a lower probability for a saccade to fall near the target, with a constant low entropy outside the optimal time window. We suggest a modulation of saccade duration, depending on the latency-related decision time (accumulation of sensory and motor evidences in favor of a goal-directed movement), normally adopted to perform efficient trajectories in goal-directed saccades. This process is impaired in cerebellar patients suggesting a role for the cerebellum in monitoring voluntary motor performance by controlling the movement onset until the ambiguity of planning is resolved.

Piu, P., Pretegiani, E., Rosini, F., Serchi, V., Zaino, D., Chiantini, T., et al. (2019). The cerebellum improves the precision of antisaccades by a latency-duration trade-off. In S. Ramat, A.G. Shaikh (a cura di), MATHEMATICAL MODELLING IN MOTOR NEUROSCIENCE: STATE OF THE ART AND TRANSLATION TO THE CLINIC. GAZE ORIENTING MECHANISMS AND DISEASE (pp. 125-139). SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS : Elsevier B.V. [10.1016/bs.pbr.2019.04.018].

The cerebellum improves the precision of antisaccades by a latency-duration trade-off

Piu P.;Pretegiani E.;Rosini F.;Serchi V.;Zaino D.;Chiantini T.;Rufa A.
2019-01-01

Abstract

The cerebellum adapts motor responses by controlling the gain of a movement, preserving its accuracy and by learning from endpoint errors. Adaptive behavior likely acts not only in the motor but also in the sensory, behavioral, and cognitive domains, thus supporting a role of cerebellum in monitoring complex brain performances. Here, we analyzed the relationship between saccade latency, duration and endpoint error of antisaccades in a group of 10 idiopathic cerebellar atrophy (ICA) patients compared to controls. The latency distribution was decomposed in a decision time and a residual time. Both groups showed a trade-off between duration and decision time, with a peak of entropy within the range of this trade-off where the information flow was maximized. In cerebellar patients, greater reductions of duration as the time of decision increased, were associated with a lower probability for a saccade to fall near the target, with a constant low entropy outside the optimal time window. We suggest a modulation of saccade duration, depending on the latency-related decision time (accumulation of sensory and motor evidences in favor of a goal-directed movement), normally adopted to perform efficient trajectories in goal-directed saccades. This process is impaired in cerebellar patients suggesting a role for the cerebellum in monitoring voluntary motor performance by controlling the movement onset until the ambiguity of planning is resolved.
9780444642547
Piu, P., Pretegiani, E., Rosini, F., Serchi, V., Zaino, D., Chiantini, T., et al. (2019). The cerebellum improves the precision of antisaccades by a latency-duration trade-off. In S. Ramat, A.G. Shaikh (a cura di), MATHEMATICAL MODELLING IN MOTOR NEUROSCIENCE: STATE OF THE ART AND TRANSLATION TO THE CLINIC. GAZE ORIENTING MECHANISMS AND DISEASE (pp. 125-139). SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS : Elsevier B.V. [10.1016/bs.pbr.2019.04.018].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1128471