LANDI, GIACOMO
LANDI, GIACOMO
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
2019-01-01 Moraes, Carolina B.; Witt, Gesa; Kuzikov, Maria; Ellinger, Bernhard; Calogeropoulou, Theodora; Prousis, Kyriakos C.; Mangani, Stefano; Di Pisa, Flavio; Landi, Giacomo; Iacono, Lucia Dello; Pozzi, Cecilia; Freitas-Junior, Lucio H.; dos Santos Pascoalino, Bruno; Bertolacini, Claudia P.; Behrens, Birte; Keminer, Oliver; Leu, Jennifer; Wolf, Markus; Reinshagen, Jeanette; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Venturelli, Alberto; Wrigley, Stephen; Karunakaran, Deepa; Kebede, Bethlehem; Pöhner, Ina; Müller, Wolfgang; Panecka-Hofman, Joanna; Wade, Rebecca C.; Fenske, Martina; Clos, Joachim; Alunda, José María; Corral, María Jesús; Uliassi, Elisa; Bolognesi, Maria Laura; Linciano, Pasquale; Quotadamo, Antonio; Ferrari, Stefania; Santucci, Matteo; Borsari, Chiara; Costi, Maria Paola; Gul, Sheraz
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity
2017-01-01 DI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Pozzi, Cecilia; Borsari, Chiara; Ferrari, Stefania; Santucci, Matteo; Santarem, Nuno; Cordeiro Da Silva, Anabela; Moraes, Carolina B.; Alcantara, Laura M.; Fontana, Vanessa; Freitas Junior, Lucio H.; Gul, Sheraz; Kuzikov, Maria; Behrens, Birte; Pöhner, Ina; Wade, Rebecca C.; Costi, Maria Paola; Mangani, Stefano
Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs
2017-01-01 Pozzi, Cecilia; DI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Costi, MARIA PAOLA; Wade, Rebecca C.; Gul, Sheraz; Cordeiro-da-Silva, Anabela; Mangani, Stefano
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections
2019-01-01 Linciano, Pasquale; Pozzi, Cecilia; Iacono, Lucia Dello; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Santarem, Nuno; Baptista, Catarina; Franco, Caio; Moraes, Carolina B; Müller, Wolfgang; Wittig, Ulrike; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Ferrari, Stefania; Pöhner, Ina; Cordeiro-da-Silva, Anabela; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
2017-01-01 Linciano, Pasquale; Dawson, Alice; Pöhner, Ina; Costa, David M; Sá, Monica S; Cordeiro da silva, Anabela; Luciani, Rosaria; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Gribbon, Philip; Reinshagen, Jeanette; Wolf, Markus; Behrens, Birte; Hannaert, Veronique; Michels, Paul A. M; Nerini, Erika; Pozzi, Cecilia; DI PISA, Flavio; Landi, Giacomo; Santarem, Nuno; Ferrari, Stefania; Saxena, Puneet; Lazzari, Sandra; Cannazza, Giuseppe; Freitas junior, Lucio H; Moraes, Carolina B; Pascoalino, Bruno S; Alcântara, Laura M; Bertolacini, Claudia P; Fontana, Vanessa; Wittig, Ulrike; Müller, Wolfgang; Wade, Rebecca C; Hunter, William N; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor
2020-01-01 Landi, Giacomo; Linciano, Pasquale; Tassone, Giusy; Costi, Maria Paola; Mangani, Stefano; Pozzi, Cecilia
Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1
2022-01-01 Pöhner, Ina; Quotadamo, Antonio; Panecka-Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Costi, Maria P; Venturelli, Alberto; Wade, Rebecca C
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs
2016-01-01 Borsari, Chiara; Lucian, Rosaria; Pozzi, Cecilia; Poehner, Ina; Henrich, Stefan; Trande, Matteo; Cordeiro Da silva, Anabela; Santarem, Nuno; Baptista, Catarina; Tait, Annalisa; DI PISA, Flavio; DELLO IACONO, Lucia; Landi, Giacomo; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Gribbon, Philip; Kohler, Manfred; Keminer, Oliver; Behrens, Birte; Costantino, Luca; Nevado, Paloma Tejera; Bifeld, Eugenia; Eick, Julia; Clos, Joachim; Torrado, Juan; Jiménez Antón, María D.; Corral, María J.; Alunda, José Ma; Pellati, Federica; Wade, Rebecca C.; Ferrari, Stefania; Mangani, Stefano; Costi, Maria Paola
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases
2021-01-01 Santucci, Matteo; Luciani, Rosaria; Gianquinto, Eleonora; Pozzi, Cecilia; Pisa, Flavio di; Dello Iacono, Lucia; Landi, Giacomo; Tagliazucchi, Lorenzo; Mangani, Stefano; Spyrakis, Francesca; Costi, Maria Paola
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors
2019-01-01 Landi, Giacomo; Linciano, Pasquale; Borsari, Chiara; Bertolacini, Claudia P; Moraes, Carolina B; Cordeiro-da-Silva, Anabela; Gul, Sheraz; Witt, Gesa; Kuzikov, Maria; Costi, Maria Paola; Pozzi, Cecilia; Mangani, Stefano
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents
2024-01-01 Linciano, Pasquale; Pozzi, Cecilia; Tassone, Giusy; Landi, Giacomo; Mangani, Stefano; Santucci, Matteo; Luciani, Rosaria; Ferrari, Stefania; Santarem, Nuno; Tagliazucchi, Lorenzo; Cordeiro-da-Silva, Anabela; Tonelli, Michele; Tondi, Donatella; Bertarini, Laura; Gul, Sheraz; Witt, Gesa; B Moraes, Carolina; Costantino, Luca; Paola Costi, Maria
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform | 1-gen-2019 | Moraes, Carolina B.; Witt, Gesa; Kuzikov, Maria; Ellinger, Bernhard; Calogeropoulou, Theodora; Prousis, Kyriakos C.; Mangani, Stefano; Di Pisa, Flavio; Landi, Giacomo; Iacono, Lucia Dello; Pozzi, Cecilia; Freitas-Junior, Lucio H.; dos Santos Pascoalino, Bruno; Bertolacini, Claudia P.; Behrens, Birte; Keminer, Oliver; Leu, Jennifer; Wolf, Markus; Reinshagen, Jeanette; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Venturelli, Alberto; Wrigley, Stephen; Karunakaran, Deepa; Kebede, Bethlehem; Pöhner, Ina; Müller, Wolfgang; Panecka-Hofman, Joanna; Wade, Rebecca C.; Fenske, Martina; Clos, Joachim; Alunda, José María; Corral, María Jesús; Uliassi, Elisa; Bolognesi, Maria Laura; Linciano, Pasquale; Quotadamo, Antonio; Ferrari, Stefania; Santucci, Matteo; Borsari, Chiara; Costi, Maria Paola; Gul, Sheraz | - | |
| Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity | 1-gen-2017 | DI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Pozzi, Cecilia; Borsari, Chiara; Ferrari, Stefania; Santucci, Matteo; Santarem, Nuno; Cordeiro Da Silva, Anabela; Moraes, Carolina B.; Alcantara, Laura M.; Fontana, Vanessa; Freitas Junior, Lucio H.; Gul, Sheraz; Kuzikov, Maria; Behrens, Birte; Pöhner, Ina; Wade, Rebecca C.; Costi, Maria Paola; Mangani, Stefano | - | |
| Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs | 1-gen-2017 | Pozzi, Cecilia; DI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Costi, MARIA PAOLA; Wade, Rebecca C.; Gul, Sheraz; Cordeiro-da-Silva, Anabela; Mangani, Stefano | - | |
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections | 1-gen-2019 | Linciano, Pasquale; Pozzi, Cecilia; Iacono, Lucia Dello; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Santarem, Nuno; Baptista, Catarina; Franco, Caio; Moraes, Carolina B; Müller, Wolfgang; Wittig, Ulrike; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Ferrari, Stefania; Pöhner, Ina; Cordeiro-da-Silva, Anabela; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola | - | |
| Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery | 1-gen-2017 | Linciano, Pasquale; Dawson, Alice; Pöhner, Ina; Costa, David M; Sá, Monica S; Cordeiro da silva, Anabela; Luciani, Rosaria; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Gribbon, Philip; Reinshagen, Jeanette; Wolf, Markus; Behrens, Birte; Hannaert, Veronique; Michels, Paul A. M; Nerini, Erika; Pozzi, Cecilia; DI PISA, Flavio; Landi, Giacomo; Santarem, Nuno; Ferrari, Stefania; Saxena, Puneet; Lazzari, Sandra; Cannazza, Giuseppe; Freitas junior, Lucio H; Moraes, Carolina B; Pascoalino, Bruno S; Alcântara, Laura M; Bertolacini, Claudia P; Fontana, Vanessa; Wittig, Ulrike; Müller, Wolfgang; Wade, Rebecca C; Hunter, William N; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola | - | |
| High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor | 1-gen-2020 | Landi, Giacomo; Linciano, Pasquale; Tassone, Giusy; Costi, Maria Paola; Mangani, Stefano; Pozzi, Cecilia | - | |
| Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1 | 1-gen-2022 | Pöhner, Ina; Quotadamo, Antonio; Panecka-Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Costi, Maria P; Venturelli, Alberto; Wade, Rebecca C | - | |
| Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs | 1-gen-2016 | Borsari, Chiara; Lucian, Rosaria; Pozzi, Cecilia; Poehner, Ina; Henrich, Stefan; Trande, Matteo; Cordeiro Da silva, Anabela; Santarem, Nuno; Baptista, Catarina; Tait, Annalisa; DI PISA, Flavio; DELLO IACONO, Lucia; Landi, Giacomo; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Gribbon, Philip; Kohler, Manfred; Keminer, Oliver; Behrens, Birte; Costantino, Luca; Nevado, Paloma Tejera; Bifeld, Eugenia; Eick, Julia; Clos, Joachim; Torrado, Juan; Jiménez Antón, María D.; Corral, María J.; Alunda, José Ma; Pellati, Federica; Wade, Rebecca C.; Ferrari, Stefania; Mangani, Stefano; Costi, Maria Paola | - | |
| Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases | 1-gen-2021 | Santucci, Matteo; Luciani, Rosaria; Gianquinto, Eleonora; Pozzi, Cecilia; Pisa, Flavio di; Dello Iacono, Lucia; Landi, Giacomo; Tagliazucchi, Lorenzo; Mangani, Stefano; Spyrakis, Francesca; Costi, Maria Paola | - | |
| Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors | 1-gen-2019 | Landi, Giacomo; Linciano, Pasquale; Borsari, Chiara; Bertolacini, Claudia P; Moraes, Carolina B; Cordeiro-da-Silva, Anabela; Gul, Sheraz; Witt, Gesa; Kuzikov, Maria; Costi, Maria Paola; Pozzi, Cecilia; Mangani, Stefano | - | |
| The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents | 1-gen-2024 | Linciano, Pasquale; Pozzi, Cecilia; Tassone, Giusy; Landi, Giacomo; Mangani, Stefano; Santucci, Matteo; Luciani, Rosaria; Ferrari, Stefania; Santarem, Nuno; Tagliazucchi, Lorenzo; Cordeiro-da-Silva, Anabela; Tonelli, Michele; Tondi, Donatella; Bertarini, Laura; Gul, Sheraz; Witt, Gesa; B Moraes, Carolina; Costantino, Luca; Paola Costi, Maria | - |