Sfoglia per Autore
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators
2020-01-01 Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity
2020-01-01 Mugnaini, C.; Sannio, F.; Brizzi, A.; Del Prete, R.; Simone, T.; Ferraro, T.; De Luca, F.; Corelli, F.; Docquier, J. D.
The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives
2020-01-01 Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; M Paola, Castelli; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico
Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats
2019-01-01 Maccioni, Paola; Fara, Federica; Lorrai, Irene; Acciaro, Carla; Mugnaini, Claudia; Corelli, Federico; Colombo, Giancarlo
Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats
2019-01-01 Lorrai, Irene; Contini, Andrea; Luigi Gessa, Gian; Mugnaini, Claudia; Corelli, Federico; Colombo, Giancarlo; Maccioni, Paola
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors
2019-01-01 Cioni, Chiara; Tassi, Maristella; Marotta, Giuseppe; Mugnaini, Claudia; Corelli, Federico; Annunziata, Pasquale
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease
2019-01-01 Mugnaini, Claudia; Rabbito, Alessandro; Brizzi, Antonella; Palombi, Nastasja; Petrosino, Stefania; Verde, Roberta; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico
Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues
2019-01-01 Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Fara, Federica; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors
2017-01-01 Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Zaru, Alessandro; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico
USO DI DERIVATI DELL’ACIDO 2-AMMINOTIOFEN-3- CARBOSSILICO PER IL TRATTAMENTO DELLE DIPENDENZE DA CIBO
2016-01-01 Colombo, Giancarlo; Carai, Mauro; Gessa Gian, Luigi; Mugnaini, Claudia; Corelli, Federico; Maccioni, Paola
Chemistry of GABAB receptor ligands: focus on agonists and antagonists
2016-01-01 Corelli, Federico; Mugnaini, Claudia
The allosteric modulation of the GABAB receptor: a medicinal chemistry perspective
2016-01-01 Mugnaini, Claudia; Corelli, Federico
Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress
2016-01-01 Aiello, F.; Badolato, M.; Pessina, Federica; Sticozzi, C.; Maestrini, Vanessa; Aldinucci, C.; Luongo, L.; Guida, F.; Ligresti, A.; Artese, A.; Allarà, M.; Costa, G.; Frosini, Maria; Schiano Morello, A.; De Petrocellis, L.; Valacchi, G.; Alcaro, S.; Maione, S.; Di Marzo, V.; Corelli, Federico; Brizzi, Antonella
Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy
2016-01-01 Sgaragli, Giampietro; Frosini, Maria; Saponara, Simona; Corelli, Federico
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility
2016-01-01 Mugnaini, Claudia; Brizzi, Antonella; Ligresti, Alessia; Allarà, Marco; Lamponi, Stefania; Vacondio, Federica; Silva, Claudia; Mor, Marco; Di Marzo, Vincenzo; Corelli, Federico
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor
2016-01-01 Maccioni, Paola; Lorrai, Irene; Carai, Mauro A. M.; Riva, Antonella; Morazzoni, Paolo; Mugnaini, Claudia; Corelli, Federico; Gessa, Gian Luigi; Colombo, Giancarlo
Total Synthesis of δ-Sanshool and Analogues Thereof
2016-01-01 Mugnaini, Claudia; Corelli, Federico
Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol.
2015-01-01 Colombo, G.; Lobina, C.; Maccioni, P.; Carai, M. A. M.; Lorrai, I.; Zaru, A.; Contini, A.; Mugnaini, Claudia; Corelli, Federico; Gessa, G.
Inhibition of alcohol self-administration by positive allosteric modulators of the GABA(B) receptor in rats: lack of tolerance and potentiation of baclofen
2015-01-01 Maccioni, P.; Vargiolu, D.; Thomas, A.; Malherbe, P.; Mugnaini, Claudia; Corelli, Federico; Leite Morris, K.; Gessa, G. L.; Colombo, G.
Ligandi TRPV1
2014-01-01 Brizzi, Antonella; Corelli, Federico; Aiello, Francesca
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators | 1-gen-2020 | Mugnaini, Claudia; Brizzi, Antonella; Mostallino, Rafaela; Paola Castelli, Maria; Corelli, Federico | - | |
| Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity | 1-gen-2020 | Mugnaini, C.; Sannio, F.; Brizzi, A.; Del Prete, R.; Simone, T.; Ferraro, T.; De Luca, F.; Corelli, F.; Docquier, J. D. | - | |
| The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives | 1-gen-2020 | Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; M Paola, Castelli; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico | - | |
| Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats | 1-gen-2019 | Maccioni, Paola; Fara, Federica; Lorrai, Irene; Acciaro, Carla; Mugnaini, Claudia; Corelli, Federico; Colombo, Giancarlo | - | |
| Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats | 1-gen-2019 | Lorrai, Irene; Contini, Andrea; Luigi Gessa, Gian; Mugnaini, Claudia; Corelli, Federico; Colombo, Giancarlo; Maccioni, Paola | - | |
| A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors | 1-gen-2019 | Cioni, Chiara; Tassi, Maristella; Marotta, Giuseppe; Mugnaini, Claudia; Corelli, Federico; Annunziata, Pasquale | - | |
| Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease | 1-gen-2019 | Mugnaini, Claudia; Rabbito, Alessandro; Brizzi, Antonella; Palombi, Nastasja; Petrosino, Stefania; Verde, Roberta; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico | - | |
| Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues | 1-gen-2019 | Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Fara, Federica; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico | - | |
| Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors | 1-gen-2017 | Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Zaru, Alessandro; Carai, Mauro A. M.; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico | - | |
| USO DI DERIVATI DELL’ACIDO 2-AMMINOTIOFEN-3- CARBOSSILICO PER IL TRATTAMENTO DELLE DIPENDENZE DA CIBO | 1-gen-2016 | Colombo, Giancarlo; Carai, Mauro; Gessa Gian, Luigi; Mugnaini, Claudia; Corelli, Federico; Maccioni, Paola | - | |
| Chemistry of GABAB receptor ligands: focus on agonists and antagonists | 1-gen-2016 | Corelli, Federico; Mugnaini, Claudia | - | |
| The allosteric modulation of the GABAB receptor: a medicinal chemistry perspective | 1-gen-2016 | Mugnaini, Claudia; Corelli, Federico | - | |
| Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress | 1-gen-2016 | Aiello, F.; Badolato, M.; Pessina, Federica; Sticozzi, C.; Maestrini, Vanessa; Aldinucci, C.; Luongo, L.; Guida, F.; Ligresti, A.; Artese, A.; Allarà, M.; Costa, G.; Frosini, Maria; Schiano Morello, A.; De Petrocellis, L.; Valacchi, G.; Alcaro, S.; Maione, S.; Di Marzo, V.; Corelli, Federico; Brizzi, Antonella | - | |
| Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy | 1-gen-2016 | Sgaragli, Giampietro; Frosini, Maria; Saponara, Simona; Corelli, Federico | - | |
| Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility | 1-gen-2016 | Mugnaini, Claudia; Brizzi, Antonella; Ligresti, Alessia; Allarà, Marco; Lamponi, Stefania; Vacondio, Federica; Silva, Claudia; Mor, Marco; Di Marzo, Vincenzo; Corelli, Federico | - | |
| Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor | 1-gen-2016 | Maccioni, Paola; Lorrai, Irene; Carai, Mauro A. M.; Riva, Antonella; Morazzoni, Paolo; Mugnaini, Claudia; Corelli, Federico; Gessa, Gian Luigi; Colombo, Giancarlo | - | |
| Total Synthesis of δ-Sanshool and Analogues Thereof | 1-gen-2016 | Mugnaini, Claudia; Corelli, Federico | - | |
| Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol. | 1-gen-2015 | Colombo, G.; Lobina, C.; Maccioni, P.; Carai, M. A. M.; Lorrai, I.; Zaru, A.; Contini, A.; Mugnaini, Claudia; Corelli, Federico; Gessa, G. | - | |
| Inhibition of alcohol self-administration by positive allosteric modulators of the GABA(B) receptor in rats: lack of tolerance and potentiation of baclofen | 1-gen-2015 | Maccioni, P.; Vargiolu, D.; Thomas, A.; Malherbe, P.; Mugnaini, Claudia; Corelli, Federico; Leite Morris, K.; Gessa, G. L.; Colombo, G. | - | |
| Ligandi TRPV1 | 1-gen-2014 | Brizzi, Antonella; Corelli, Federico; Aiello, Francesca | - |
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